نتایج جستجو برای: آنتی tumor necrosis factor tnf

تعداد نتایج: 1254222  

Journal: :Cardiovascular research 1998
R Ferrari

Ž . Tumor necrosis factor TNF gained its popularity in the world of biology and medicine in a weird way. In 1985, Old in New York City discovered the presence of a Ž . protein in blood after lipopolysaccharide LPS injection, w x which is able to induce necrosis of some mouse tumors 1 . He called it ‘tumor necrosis factor’, a term actually coined in the 1970s. At the same time and, virtually, on...

Journal: :Cancer research 1999
P C Wu H R Alexander J Huang P Hwu M Gnant A C Berger E Turner O Wilson S K Libutti

Tumor necrosis factor (TNF)-alpha is a potent anticancer agent that seems to selectively target tumor-associated vasculature resulting in hemorrhagic necrosis of tumors without injury to surrounding tissues. The major limitation in the clinical use of TNF has been severe dose-limiting toxicity when administered systemically. However, when administered in isolated organ perfusion it results in r...

Journal: :Translational cancer research 2023

Background: Necroptosis is a novel programmed cell death pathway proposed in 2005, which mainly activated by the tumor necrosis factor (TNF) family and mediates cellular disassembly via receptor interacting serine/threonine kinase 1 (RIPK1), 3 (RIPK3) mixed lineage domain like pseudokinase (MLKL). We tried to analyze relationship of necroptosis-related genes (NRGs) expression with colon adenoca...

2001
Peter C. Wu H. Richard Alexander James Huang Patrick Hwu Michael Gnant Adam C. Berger Ewa Turner Olga Wilson Steven K. Libutti

Tumor necrosis factor (TNF)-a is a potent anticancer agent that seems to selectively target tumor-associated vasculature resulting in hemorrhagic necrosis of tumors without injury to surrounding tissues. The major limitation in the clinical use of TNF has been severe dose-limiting toxicity when administered systemically. However, when administered in isolated organ perfusion it results in regre...

Journal: :dental research journal 0
shirin zahra farhad shahram amini amir khalilian majid barekatain morvarid mafi mehrdad barekatain

background: despite the outbreak in dental science, oral and dental complications in alzheimer are of the unsolved problems. it is assumed that tumor necrosis factor-α, which is a key factor in alzheimer, has a relation with periodontal complications in patients with alzheimer disease. the present study evaluated the effect of chronic periodontitis on serum levels of tumor necrosis factor-α in ...

Background: The tumor necrosis factor alpha (TNFα) is a cytokine that produced principally by monocyte/macrophages and T lymphocytes, respectively. TNFα is recognized as the primary mediator of immunity in inflammation reaction.  One important application of Tumor Necrosis Factor Receptor 2 (TNFR2) is for the treatment of autoimmune diseases like rheumatoid arthritis (RA).<br /...

Journal: :middle east journal of cancer 0
somayeh dadras shiraz institute for cancer research, shiraz university of medical sciences, shiraz, iran mahboobeh razmkhah shiraz institute for cancer research, shiraz university of medical sciences, shiraz, iran bijan khademi department of otorhinolaryngology, shiraz university of medical sciences, shiraz, iran mehdi ansari shiraz institute for cancer research, shiraz university of medical sciences, shiraz, iran ahmad hosseini shiraz institute for cancer research, shiraz university of medical sciences, shiraz, iran abbas ghaderi shiraz institute for cancer research, shiraz university of medical sciences, shiraz, iran

background: because of its effect on speech and swallowing, laryngeal squamous cell carcinoma is a devastating disease which has been shown to have a poor survival rate. abundant research is being carried out in search of novel biomarkers that can aid the process of diagnosis and treatment of this disease. fxyd3, a modulator of na/k-atpase, is presented as a biomarker in some cancers. fxyd3 exp...

Journal: :European journal of pharmacology 1995
M Leist A Wendel

The protein glycosylation inhibitor tunicamycin protected male BALB/c mice from tumor necrosis factor alpha-induced liver failure. Tunicamycin also inhibited tumor necrosis factor-induced cell death in primary hepatocyte cultures with a median inhibitory concentration of 8 nM, but not in the tumor cell line WEHI 164 clone 13. Hepatocyte death in our culture system was characterized by DNA fragm...

Amin Soleymanian Fahimeh Ramezani Tehrani, Fatemeh Rezayat Mehri Hajiaghayi Mehrnaz Mesdaghi Nazanin Ghasemi

Background: Polycystic Ovarian Syndrome (PCOS) is a pro-inflammatory condition that supports the development of metabolic aberration and ovarian dysfunction. Chronic inflammation and the increased levels of androgens in this group of patients and their impact on the immune system may increase the risk of developing malignancies, including ovarian cancer. Thus, we interacted ovarian tumor cells ...

2007
Calin Popa Mihai G. Netea Piet L. C. M. van Riel Jos W. M. van der Meer Anton F. H. Stalenhoef

The recent insight that inflammation contributes to the development of atherosclerosis and type 2 diabetes mellitus constitutes a major breakthrough in understanding the mechanisms underlying these conditions. In addition, it opens the way for new therapeutic approaches that might eventually decrease the prevalence of these public health problems. Tumor necrosis factor-a (TNF-a) has been shown ...

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