نتایج جستجو برای: آمیلوییدوز amyloidoses

تعداد نتایج: 269  

2011
Yasuhiro Yamamoto Kenkichi Takase Junji Kishino Megumi Fujita Noboru Okamura Toshiyuki Sakaeda Masafumi Fujimoto Tatsurou Yagami

15-deoxy-Δ(12,14)-prostaglandin J(2) (15d-PGJ(2)) is one of factors contributed to the neurotoxicity of amyloid β (Aβ), a causative protein of Alzheimer's disease. Type 2 receptor for prostaglandin D(2) (DP2) and peroxysome-proliferator activated receptorγ (PPARγ) are identified as the membrane receptor and the nuclear receptor for 15d-PGJ(2), respectively. Previously, we reported that the cyto...

2015
Jianzong Li Yu Feng Xiaoyun Wang Jing Li Wen Liu Li Rong Jinku Bao Lukasz Kurgan Vladimir N. Uversky

The sequence-structure-function paradigm of proteins has been changed by the occurrence of intrinsically disordered proteins (IDPs). Benefiting from the structural disorder, IDPs are of particular importance in biological processes like regulation and signaling. IDPs are associated with human diseases, including cancer, cardiovascular disease, neurodegenerative diseases, amyloidoses, and severa...

2013
Antonios C. Tsolis Nikos C. Papandreou Vassiliki A. Iconomidou Stavros J. Hamodrakas

The purpose of this work was to construct a consensus prediction algorithm of 'aggregation-prone' peptides in globular proteins, combining existing tools. This allows comparison of the different algorithms and the production of more objective and accurate results. Eleven (11) individual methods are combined and produce AMYLPRED2, a publicly, freely available web tool to academic users (http://b...

Journal: :The Journal of clinical investigation 1988
M R Wallace F E Dwulet E C Williams P M Conneally M D Benson

In the last several years, five human plasma prealbumin (transthyretin) variants have been discovered in association with hereditary amyloidosis, a late-onset fatal disorder. We recently studied a patient of German descent with peripheral neuropathy and bowel dysfunction. Biopsied rectal tissue contained amyloid that stained with anti-human prealbumin. Amino acid sequence analysis of the patien...

Journal: :Annual review of biochemistry 2006
Fabrizio Chiti Christopher M Dobson

Peptides or proteins convert under some conditions from their soluble forms into highly ordered fibrillar aggregates. Such transitions can give rise to pathological conditions ranging from neurodegenerative disorders to systemic amyloidoses. In this review, we identify the diseases known to be associated with formation of fibrillar aggregates and the specific peptides and proteins involved in e...

2013
Giampaolo Merlini Ashutosh D. Wechalekar Giovanni Palladini

The systemic amyloidoses comprise an increasing number of diseases characterized by multiorgan deposition of misfolded and aggregated autologous proteins as b-pleated sheet fibrils. Immunoglobulin light chain (AL) amyloidosis is the most common (incidence ;10 patients per million per year) and the most severe because it often targets the heart. A small, usually indolent plasma cell (PC) clone s...

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