BACKGROUND Abnormal uterine bleeding is commonly associated with progestin-only contraceptives, including depot medroxyprogesterone acetate (DMPA), and remains the main reason why these agents are discontinued. Matrix metalloproteinases (MMP), enzymes which degrade specific extracellular matrix components, and leukocytes are implicated in menstruation. Alteration in endometrial MMP-9 and leukoc...

This retrospective study looked at the bone mass density of women using combined oral contraception (n = 59), depot-medroxyprogesterone acetate (DMPA) (n = 34) or controls (n = 62) who had not used steroid contraception for 6 months. The groups were matched for body mass index, age, smoking, alcohol consumption, caffeine consumption and exercise. There was no matching for family history nor was...

In the title centrosymmetric dinuclear complex, [Tm(2)(C(10)H(11)O(4))(6)(C(12)H(8)N(2))(2)], the unique Tm(III) ion is coordin-ated by five 3,4-dimethoxy-phenyl-acetate (DMPA) ligands and and a bis-chelating 1,10-phenanthroline (phen) ligand via seven O atoms and two N atoms, forming a distorted tricapped trigonal-prismatic environment. The DMPA ligands coordin-ate in the bis-chelate, bridging...

Surveys indicate that one form of acceptable male hormonal contraception would consist of injections given at 2- to 3-month intervals. This report describes a study of depot medroxyprogesterone acetate (DMPA) and testosterone undecanoate (TU) injected at 8-wk intervals for suppression of spermatogenesis in healthy Chinese men. After screening, 30 healthy volunteers were enrolled and randomly as...

This retrospective study looked at the bone mass density of women using combined oral contraception (n = 59), depot-medroxyprogesterone acetate (DMPA) (n = 34) or controls (n = 62) who had not used steroid contraception for 6 months. The groups were matched for body mass index, age, smoking, alcohol consumption, caffeine consumption and exercise. There was no matching for family history nor was...

Galactorrhea is rarely mentioned as a possible side effect of the use of Depot-Medroxyprogesterone Acetate (DMPA). Over the last few years, we have noticed an increased number of patients complaining of galactorrhea. A review of clinical data showed that between 1999 and 2005, 360 adolescents in our clinic used DMPA for at least 6 months. After medical follow-up, 13 (3.6%) of these patients wer...

BACKGROUND Depot medroxyprogesterone acetate (DMPA) has been linked to human immunodeficiency virus type 1 (HIV-1) acquisition. METHODS Vaginal microbiota of women using DMPA for up to 2 years were cultured. Mucosal immune cell populations were measured by immunohistological staining. RESULTS Over 12 months, the proportion with H2O2-positive lactobacilli decreased (n = 32; 53% vs 27%; P = ....

currently using long-acting injectable contraceptives, mostly in developing countries, and the number of users is increasing. It is generally believed that the popularity of such methods would considerably increase if they were further improved. Table 1 describes the current status of injectable contraceptives which are either available in the market or under development. Injectable hormonal co...

BACKGROUND In vitro, animal, biological and observational clinical studies suggest that some hormonal methods, particularly depot medroxyprogesterone acetate - DMPA, may increase women's risk of HIV acquisition. DMPA is the most common contraceptive used in many countries worst affected by the HIV epidemic. To provide robust evidence for contraceptive decision-making among women, clinicians and...

This retrospective study looked at the bone mass density of women using combined oral contraception (n = 59), depot-medroxyprogesterone acetate (DMPA) (n = 34) or controls (n = 62) who had not used steroid contraception for 6 months. The groups were matched for body mass index, age, smoking, alcohol consumption, caffeine consumption and exercise. There was no matching for family history nor was...