background: photodynamic therapy (pdt) is a promising therapeutic modality for the treatment of cancer and other diseases. in this study, the epidermoid carcinoma cell line a431 and the normal fibroblasts were used to investigate whether gold nanoparticles (gnps) can induce an increase in cell death during pdt using 5-aminolevulinic acid (5-ala) as a photosensitizer. methods: human fibroblast a...

During the last two decades, numerous observed data obtained by various physical techniques, also supported molecular modeling approaches, have highlighted structuring features of tripeptides, as well their aggregation properties. Herein, we focus on structural dynamics four trimers, i.e., Gly-Gly-Gly, Gly-Ala-Gly, Ala-Ala-Ala and Ala-Phe-Ala, in an aqueous environment. Density functional theor...

background: cryopreservation of pre-antral follicles is a hopeful technique to preserve female fertility. the aim of the present study was to evaluate reactive oxygen species (ros) and total antioxidant capacity (tac) levels of mouse vitrified pre-antral follicles in the presence of alpha lipoic acid (ala). methods: isolated pre-antral follicles (140–150 µm in diameter) were divided into vitrif...

Introduction: This study evaluated the effects of pretreatments with melatonin (MT), and Alpha Lipoic acid (ALA) on lopinavir/ritonavir (LPV/r) -induced serum levels of creatinine (Cr), urea (U), uric acid (Ua) and kidney levels of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH) and catalase (CAT) in male albino rats. Effects of treatments with MT and ALA were also evaluate...

به کمک شبیه ­سازی دینامیک مولکولی می ­توان تحلیل کوتاه مدت در مقیاس زمانی چند ده پیکوثانیه ­ای را برای مواد آسیب دیده­ی تابشی مورد مطالعه قرار داد. بر همین مبنا این ­سازی، تعداد تعادلی عیوب نقطه بین ­نشین و تهی ­جای مختصات مکانی آن­ها آهن- آلفا دست آورده شد. سپس با استفاده از نتایج حاصل شده، مونت کارلوی جنبشی شیء منظور بررسی تأثیر بازپخت آلفای انجام نشان دادند که یکنواخت دیده­ ی تنها خوشه جای ب...

In vitro characterization experiments revealed the formations of 3-(trans-2’-aminocyclopropyl)alanine ((3-Acp)Ala) and 3-(trans-2’-nitrocyclopropyl)alanine ((3-Ncp)Ala) are originated via two homologous proteins, BelK HrmI, which regioselectively catalyze N?-oxygenation l-lysine. The enzymes belong to emerging heme-oxygenase-like diiron oxidase oxygenase (HDO) superfamily catalytic center is va...