BACKGROUND To explore the activity and tolerability of gemcitabine (GEM) and carboplatin (CBDCA) in non-small-cell lung cancer (NSCLC) we tested four administration sequences on H460 NSCLC cells, and at the same time performed a randomized phase II trial using analogous schedules. PATIENTS AND METHODS GEM was given first in two in vitro sequences, and CBDCA first in the other two; interaction...

IDENTITY Citation · Winters JC, Dmochowski RR, Goldman HB, Herndon CD, Kobashi KC, Kraus SR, Lemack GE, Nitti VW, Rovner ES, Wein AJ. Adult urodynamics: American Urological Association (AUA)/Society of Urodynamics, Female Pelvic Medicine & Urogenital Reconstruction (SUFU) guideline. Linthicum (MD): American Urological Association (AUA); 2012 Apr. 30 p. [119 references] Date Released · 2012 GEM ...

Abstract. This paper considers gauge-invariant and covariant gravitational perturbations on arbitrary vacuum locally rotationally symmetric (LRS) class II space-times. Ultimately, we derive four decoupled equations governing four specific combinations of the gravito-electromagnetic (GEM) 2-tensor harmonic amplitudes. We use the gauge-invariant and covariant 1+1+2 formalism which Clarkson and Ba...

Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a major human pandemic. Germline-encoded mycolyl lipid-reactive (GEM) T cells are donor-unrestricted and recognize CD1b-presented mycobacterial mycolates. However, the molecular requirements governing mycolate antigenicity for the GEM T cell receptor (TCR) remain poorly understood. Here, we demonstrate CD1b expression in TB granul...

BACKGROUND We have recently completed a large phase III trial in advanced non-small cell lung cancer (NSCLC) in the elderly which showed that the combination of gemcitabine (GEM) plus vinorelbine (VNR), with GEM administered first, did not improve any outcome as compared with each single drug. MATERIALS AND METHODS The anti-tumor efficacy of different sequences of administration of GEM and VN...

Among the most effective strategies for changing the process and outcomes of clinical care are those that make use of computer-mediated decision support. A variety of representation models that facilitate computer-based implementation of medical knowledge have been published, including the Guideline Elements Model (GEM) and the Arden Syntax for Medical Logic Modules (MLMs). We describe an XML-b...

A graph is (P5,gem)-free, when it does not contain P5 (an induced path with five vertices) or a gem (a graph formed by making an universal vertex adjacent to each of the four vertices of the induced path P4) as an induced subgraph. We present O(n2) time recognition algorithms for chordal gem-free and for (P5,gem)free graphs. Using a characterization of (P5,gem)-free graphs by their prime graphs...