Selection lines of mice, artificially selected for aggression based upon the attack latency score (ALS), were used. In order to determine the relative contribution of neonatal testosterone (T) in the development of aggression, we vary the plasma-T level in males of both selection lines on the day of birth. At 14 weeks the ALS was measured. Neonatal T treatment results in a reduction of aggressi...

BACKGROUND Membranes with increasing pore size are introduced to enhance removal of large uremic toxins with regular hemodialysis. These membranes might theoretically have higher permeability for bacterial degradation products. In this paper, permeability for bacterial degradation products of membranes of comparable composition with different pore size was investigated with a new in vitro set-u...

Soil organic carbon (SOC) represents a significant reservoir of carbon within the global carbon cycle that has been estimated to account for 1,200–1,550 Pg C to a depth of 1 m and for 2370–2450 Pg C to a depth of 2 m (Eswaran et al. 1995; Lal 2004a). Comparative estimates of organic C contained in living biomass (560 Pg) and atmospheric CO2-C (760 Pg) (Lal 2004a) indicate that variations in the...

OBJECTIVE To estimate clinical progression and resource utilisation together with the associated costs of managing children and adults with LAL Deficiency, at a tertiary referral centre in the UK. METHODS A retrospective chart review was undertaken of patients in the UK with a confirmed diagnosis of LAL Deficiency who were managed at a LAL Deficiency tertiary referral treatment centre. Patien...

LAL regulators (Large ATP-binding regulators of the LuxR family) constitute a poorly studied family of transcriptional regulators. Several regulators of this class have been identified in antibiotic and other secondary metabolite gene clusters from actinomycetes, thus they have been considered pathway-specific regulators. In this study we have obtained two disruption mutants of LAL genes from S...

Nature abounds in producing a variety of molecules. This is good thing, however, endotoxin detection requirement for an analytical assay “specificity”. Unfortunately, LAL has been found to be increasingly non-specific since the inception its use lieu rabbit pyrogen test. Fortunately, there are viable workarounds terms using Limulus-based testing where non-endotoxin reactive substance false-reac...

The Limulus amoebocyte lysate (LAL) test has replaced about 80% of the use of the rabbit pyrogen test. Ideally, human-based in vitro tests are needed, to replace the remaining use of the rabbit test and the use of the LAL test. The progress of an EU-funded project is described, in which a number of in vitro tests, based on the human fever reaction are passing through a prevalidation study on th...

OBJECTIVE Dental arch form is one of the most important characteristics of dentition. However, this dimension usually receives less attention in diagnosis or treatment planning and orthodontic patients are traditionally classified with regard to their sagittal characteristics. The objectives of this study were to investigate if a relationship exists between the dental arch width (transverse dim...

Lysosomal acid lipase deficiency (LAL-D) is still a little recognized genetic disease with significant morbidity and mortality in children and adults. This document provides guidance on when to suspect LAL-D and how to diagnose it. It is recommended to add lysosomal acid lipase deficiency to the List of differential diagnoses of sepsis, oncological diseases, storage diseases, persistent diarrhe...