Lung cancer is the most common malignant tumor with increasing angiopoietin-2 (Ang-2) and a high rate of metastasis. However, the mechanism of Ang-2 enhancing tumor proliferation and facilitating metastasis remains to be clarified. In this study, Ang-2 expression and its gene transcription on effects of biological behaviors and epithelial-mesenchymal transition (EMT) were investigated in lung c...

The goal of our study was to explore the significant association between a non-protein coding single nucleotide polymorphism (SNP) rs4977574 of CDKN2BAS gene and coronary heart disease (CHD). A total of 590 CHD cases and 482 non-CHD controls were involved in the present association study. A strong association of rs4977574 with CHD was observed in females (genotype: p=0.002; allele: p=0.002, odd...

The association between a binary variable Y and a variableX with an at least ordinal measurement scale might be examined by selecting a cutpoint in the range of X and then performing an association test for the obtained 2 × 2 contingency table using the χ2 statistic. The distribution of the maximally selected χ2 statistic (i.e. the maximal χ2 statistic over all possible cutpoints) under the nul...

Study objectives To determine the effect of light exposure on subsequent sleep characteristics under ambulatory field conditions. Methods Twenty healthy participants were fitted with ambulatory polysomnography (PSG) and wrist-actigraphs to assess light exposure, rest-activity, sleep quality, timing, and architecture. Laboratory salivary dim-light melatonin onset was analyzed to determine endo...

OBJECTIVE The comparative crude death rates (CDR) among non-vitamin K antagonist oral anticoagulants (NOACs) are unknown. Further, whether NOACs improve survival when compared with warfarin is also unclear. We compared CDR co-reported for four NOACs combined or separately versus warfarin within the US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) database. METHODS ...

BACKGROUND Alterations in Theory-of-Mind (ToM) are associated with psychotic disorder. In addition, studies in children have documented that alterations in ToM are associated with Psychotic Experiences (PE). Our aim was to examine associations between an exaggerated type of ToM (HyperToM) and PE in children. Children with this type of alteration in ToM infer mental states when none are obviousl...

CCC-r chart extended approach of CCC charts, is a technique applied when nonconforming items are rarely observed. However, it is usually assumed that the inspection process is perfect in the implementation control charts imperfect inspections may have a significant impact on the performance of the control chart and setting the control limits. This paper first investigates the ...

The assessment of the locomotor system functionality is great importance for both athletes and those not doing any kind sport. It assumed that a structured physical activity has number positive effects to system. study included 31 samples are active 25 involved in training process. aim was evaluate effect process on functional stability mobility results indicate there significant statistical di...

Abstract Purpose To study the features of course uncontrolled arterial hypertension (AH) in Aral Sea region with identification prevalence various genotypes angiotensinogen (AGT) gene patients uncomplicated hypertensive crisis. Methods The genetic part included 94 crisis, an average age 55.3±8.6 years, 54 (58.3%)women and 40 men (41.7%). control group consisted 50 healthy women men, 52.7±6.4 ye...

Interleukin (IL)-17 is a proinflammatory cytokine mainly secreted by activated T helper 17 cells and involved in inflammatory immune responses. This study aimed to investigate the association between IL-17 variants as well as serum IL-17 levels with gout in male Chinese Han individuals. A total of 1,101 male gout patients and 1,239 ethic-matched controls were enrolled. Genetic distributions of ...