Gastric cancer is the fourth most common cancer type and the second leading cause of cancer‑associated mortality worldwide. Metastasis is a crucial feature of its progression. DNA methylation provides a key epigenetic signature in the epigenetic regulation pathway, and is implicated in transcriptional regulation. CpG sites, which are associated with gene transcriptional activity, are underrepre...

The main focus of this paper is the implementation of mixed-signal peak current mode control in low-power dc–dc converters for portable applications. A DAC is used to link the digital voltage loop compensator to the analog peak current mode loop. Conventional DAC architectures, such as flash or are not suitable due to excessive power consumption and limited bandwidth of the reconstruction filte...

INTRODUCTION Among patients with acute myeloid leukemia (AML), the DACO-016 randomized study showed reduction in mortality for decitabine [Dacogen(®) (DAC), Eisai Inc., Woodcliff Lake, NJ, USA] compared with treatment choice (TC): at primary analysis the hazard ratio (HR) was 0.85 (95% confidence interval 0.69-1.04; stratified log-rank P = 0.108). With two interim analyses, two-sided alpha was ...

Dactylaplasia, characterized by missing central digital rays, is an inherited mouse limb malformation that depends on two genetic loci. The first locus, Dac, is an insertional mutation around the dactylin gene that is inherited as a semidominant trait. The second locus is an unlinked modifier, mdac/Mdac, that is polymorphic among inbred strains. Mdac dominantly suppresses the dactylaplasia phen...

A disturbance accommodating controller (DAC) to reject wind speed perturbations is applied on a 5MW wind turbine mounted on a tension leg platform (TLP). Multi-blade coordinate (MBC) transformation is used to address the periodicity of the floating wind turbine system. A method to apply DAC after applying MBC transformation is developed and several implementation options are presented. Simulati...

Acquired and intrinsic resistance still remains a limitation to the clinical use of 5-fluorouracil (5-FU). The contribution of epigenetic changes to the development of drug resistance remains to be elucidated. Several genes that are hypermethylated and silenced have been identified in colorectal cancer. Based on the findings described in the accompanying article, we hypothesized that acquired r...

Allograft reinfection with hepatitis C virus (HCV) occurs universally in liver transplant recipients. Corticosteroids can contribute to HCV recurrence. This randomized study evaluated HCV recurrence in HCV-positive liver allograft recipients using steroid-free immunosuppression. All patients received tacrolimus (TAC) at an initial dose of 0.10-0.15 mg/kg. The steroid-free arm (TAC/daclizumab (T...

Epigenetic analysis shows that many genes that suppress malignancy are silenced by aberrant DNA methylation in lung cancer. Many of these genes are interesting targets for reactivation by the inhibitor of DNA methylation, decitabine (5-aza-2'-deoxycytidine, DAC). A pilot study on intense dose DAC showed promising results in patients with metastatic non-small cell lung cancer (NSCLC). However, s...

I . Diets containing varying lcvels of crude protein (CP) in the range 9.5-18.5 "/b with and without supplements of diammonium citrate (DAC) as a source of non-protein nitrogen (KPN) were given to 160 growing chicks from z to 4 weeks of age, and their livers were assayed for glutamate dehydrogenase (GDH) activity. 2. Growth rate and total liver protein were increased by raising the protein leve...

This work presents implementations and tuning experiences with parallel irregular applications developed using the object oriented framework DAMPVM/DAC. It is implemented on top of DAMPVM and provides automatic partitioning of irregular divide-and-conquer (DAC) applications at runtime and dynamic mapping to processors taking into account their speeds and even loads by other user processes. New ...