To estimate the levels of folic acid, vitamin B12 and their relationship with ferritin in βthalassemia major children. Thirty children with β-thalassemia major in the age group of 4 to 8 years were studied for estimation of serum ferritin, folic acid and vitamin B12 over a period of one year. These tests were determined by means of Immulite 1000 analyzer. The statistical analysis of β-thalassem...

OBJECTIVES A health-promoting lifestyle (HPL) is a factor that affects the quality of life (QoL) in patients with beta-thalassemia (β-thalassemia). Due to the lack of studies of this issue, this study aimed to determine the association between HPL and QoL among adults with β-thalassemia. METHODS This cross-sectional (descriptive-analytic) study was conducted among 389 adult patients with β-th...

Mục tiêu: Mô tả đặc điểm thiếu máu và quá tải sắt của bệnh nhân Thalassemia tại Viện Huyết học Truyền Trung ương giai đoạn 2020 – 2022. Đối tượng phương pháp: Nghiên cứu mô cắt ngang trên 3097 điều trị tâm Thalassemia, từ 01/2020 đến 03/2022. Kết quả: Nhóm β-Thalassemia thể nặng có nồng độ huyết sắc tố trung bình thấp nhất tỉ lệ rất cao nhất. Sự khác biệt về mức giữa các là ý nghĩa thống kê (p ...

Beta-thalassemia is a life-threatening inherited blood disorder. Rapid characterization of β-globin gene mutations is necessary because of the high frequency of Malaysian β-thalassemia carriers. A combination real-time polymerase chain reaction genotyping assay using TaqMan probes was developed to confirm β-globin gene mutations. In this study, primers and probes were designed to specifically i...

introduction: the current study evaluated the value of red blood cell (rbc) indices and the corresponding cut- off points for β-thalassemia control programs in iran. materials and methods: 1,150 individuals (575 couples) with low rbc indices and normal hemoglobin a2 who had been referred to the genetic centre of isfahan, were tested during pre-marital screening analyses, in the 2 year period, 2...

background: β-thalassemia is an autosomal hemoglobinopathy with inconsistent universal distribution. among patients with thalassemia diverse non-siderotic complications distinctly influence the attribute of life, including zinc deficiency due to varied etiologies. the objective of the present study was to determine zinc levels in patients with β-thalassemia major and its correlation with matern...

Thalassemia is a hereditary condition that affects the formation of globin chains. Beta thalassemia characterized by either total loss manufacture (β-thalassemia major) or partial minor). This type inherited anemias found in Mediterranean and Southeast Asian communities. Objective: Assessment parents' knowledge regarding home health care management related to children with β-Thalassemia Major. ...

abstract β-thalassemia major (β –tm) is the most common thalassemia severe phenotype among iranians. in recent years, molecular understanding of pathogenesis of β –tm has provided a great opportunity regarding diagnostic issues. creating comprehensive molecular databases provides highly sensitive diagnostic tools for β –tm and effective prenatal diagnosis (pnd) molecular screening tests. despit...

background transfusion-induced iron overload leads to many complications in patients with β-thalassemia major. this study aimed to compare the level of iron stored in the liver and heart measured by mri t2 * with ferritin levels in these patients. materials and methods this study was done on 52 patients with β-thalassemia major aged 7 to 29 years. serum ferritin level was checked and heart and ...

The role of the laboratory in the diagnosis of thalassemia and hemoglobinopathies is crucial. The objective of our study was to compare two common methods used in hemoglobinopathy and thalassemia investigation. Hemoglobin electrophoresis and HPLC (high performance liquid chromatography) were used to investigate patients suspected with thalassemia. A total of 301 adult and child blood samples we...