Endothelial dysfunction is important in the pathophysiology of preeclampsia. No study has examined endothelial function sequentially at different gestations before development of the clinical syndrome and after delivery (to compare maternal from placental influences). We sought to determine whether endothelial function changes before the clinical development of preeclampsia. We measured skin mi...

Endothelial dysfunction is important in the pathophysiology of preeclampsia. No study has examined endothelial function sequentially at different gestations before development of the clinical syndrome and after delivery (to compare maternal from placental influences). We sought to determine whether endothelial function changes before the clinical development of preeclampsia. We measured skin mi...

Preeclampsia (PE), which is characterized by hypertension in women who have normal blood pressure before pregnancy and accompanied proteinuria, edema, major organ damage, the cause of increased mortality pregnant perinatal fetuses. So far, genistein recognized as only safe effective natural phytoestrogen without estrogen-like adverse reactions. Recent studies show that may play a significant ro...

The placenta is the special pregnancy organ that links a mother to the child for the transport of fetal nutrition through umbilical cord. Preeclampsia is a major disorder of pregnancy which mainly originates in the placenta and is associated with retarded fetal and placental growth. The aim of this study was to compare the morphometric measures of placenta in pregnancies complicated by Preeclam...

thrombophilia is a pathological state of increased blood coagulability. it causes problems during pregnancy including preeclampsia, stillbirth, repeated abortions, and detached pair. out of the most prevalent factors causing inherited thrombophilia, protein s (prs), protein c (prc), and antithrombin iii (atiii) deficiency, and factor v leiden (fvl) mutation could be mentioned. this study aimed ...

The reduced uterine perfusion pressure (RUPP) rat model of preeclampsia exhibits much of the pathology characterizing this disease, such as hypertension, inflammation, suppressed regulatory T cells (TRegs), reactive oxygen species (ROS), and autoantibodies to the ANG II type I receptor (AT1-AA) during pregnancy. The objective of this study was to determine whether supplementation of normal preg...

Dramatic hemodynamic alterations occur during a normal, healthy pregnancy with the kidneys playing a major role to ensure that these adaptive changes occur properly. Therefore, it is not surprising that a significant number of women may develop new onset renal dysfunction or exacerbation of preexisting renal disease during pregnancy. Perhaps the most commonly encountered gestational disorder is...

INTRODUCTION Preeclampsia is a complex syndrome of unknown aetiologic origin. It is characterized by the clinical triad of hypertension, edema and protenuria. Current concepts of the genesis of preeclampsia include endothelial dysfunction and oxidative stress. OBJECTIVE This study assessed the relationship between the activity of superoxide dismutase, the zincemia and the preeclampsia. METH...