Transcriptional profiling was used to identify genes and pathways that responded to intracerebroventricular injection of melanocortin-4 receptor (MC4R) agonist [Nle(4), d-Phe(7)]-α-melanocyte stimulating hormone (NDP-MSH) in pigs homozygous for the missense mutation in the MC4R, D298 allele (n = 12), N298 allele (n = 12), or heterozygous (n = 12). Food intake (FI) was measured at 12 and 24 h af...

Dandruff is a common scalp condition. The immune-microenvironment of dandruff skin remains poorly characterised and the hair follicle’s physiological immune privilege (HF IP) status in completely unknown. We hypothesised that latter might be important context dandruff-associated inflammation as HF IP expected to impact on overall immunophysiology. analysed expression biomarkers (CD200, MHC clas...

BACKGROUND/OBJECTIVES The root of Vitis amurensis Ruprecht, a sort of wild-growing grape, has been used in oriental medicine for treatment of skin ailments; however, its dermatological activity is not sufficiently understood. The aim of this study was to investigate tyrosinase inhibitory and anti-melanogenic activities of V. amurensis Ruprecht root methanol extract (VARM) in B16F10 mouse melano...

Melanocortin 4 Receptors (MC4R) merupakan turunan senyawa G protein coupled-receptors (GPCRs). MC4R berperan dalam homeostasis energi, fungsi kardiovaskular, dan sistem reproduksi. Gen ini menyandi sekitar 332 asam amino terkespresi pada hipotalamus. salah satu transmembran dengan memiliki tujuh subtipe protein. Melanocortin-pathway berhubungan pro-opiomelanocortin (POMC) aktivasi leptin sehing...

In vitro models to investigate pigmentation disorders inadequately capture the complex neuroectodermal-mesodermal signaling interplay controlling human epidermal melanogenesis. Here, we aimed at assessing suitability of a standardized ex vivo skin organ culture as rapid detection-system qualitatively and quantitatively assess effects topically or systemically applied candidate modulators, under...

OBJECTIVE The aim of this study was to verify the effects of a multidisciplinary therapy (24 weeks) on neurohormonal control of food intake, specifically in orexigenic (total ghrelin, agouti-related protein [AgRP], neuropeptide Y [NPY], and melanin-concentrating hormone) and anorexigenic factors (leptin, insulin, and alpha-melanocyte stimulating hormone [α-MSH]), in obese adolescents. METHODS...

Wu, Chia-Shan Jenny, David R. Greenwood, Janine M. Cooney, Dwayne J. Jensen, Michele A. Tatnell, Garth J. S. Cooper, and Kathleen G. Mountjoy. Peripherally administered desacetyl -MSH and -MSH both influence postnatal rat growth and associated rat hypothalamic protein expression. Am J Physiol Endocrinol Metab 291: E1372–E1380, 2006. First published July 25, 2006; doi:10.1152/ajpendo.00480.2005....

Polygonum multiflorum is a traditional Chinese medicine with a long history in hair growth promotion and hair blackening. The purpose of the study was to examine the effect and the mechanism of Polygonum multiflorum in hair blackening. C57BL/6 mice hair fade was induced with H2O2 and used in this research. Hair pigmentogenesis promotion activities of Polygonum Multiflorum Radix (PMR, raw crude ...

Previous investigations indicate that α-melanocyte-stimulating hormone (α-MSH) and certain synthetic analogues of it exert antimicrobial effects against bacteria and yeasts. However, these molecules have weak activity in standard microbiology conditions and this hampers a realistic clinical use. The aim in the present study was to identify novel peptides with broad-spectrum antimicrobial activi...

γ-Melanocyte-stimulating hormone (γ-MSH), atrial natriuretic peptide (ANP), and oxytocin have been identified as candidate hormonal mediators of the reflex natriuresis that follows acute unilateral nephrectomy (AUN). Pharmacological characterization of the third melanocortin receptor (MC3-R) indicates that it uniquely responds to physiological concentrations of γ-MSH. We tested the roles of γ-M...