Transthyretin (TTR) is a homotetrameric protein involved in human hereditary amyloidoses. The discovery and development of small molecules that inhibit the amyloid fibril formation of TTR is one of the therapeutic strategies for these diseases. Herein, we discovered that γ-mangostin (γ-M) is an effective inhibitor against the amyloid fibril formation of V30M amyloidogenic TTR. In-vitro binding ...

Dental caries occurs due to the demineralization of tooth structure caused by microorganisms in colonies called biofilms. One involved dental is Streptococcus mutans. Oral mouthwash, addition mechanical cleaning, known prevent growth oral microorganisms. Mangosteen as an anti-cancer ingredient with high anti-bacterial properties. This study aims identify effectiveness mangosteen skin extract (G...

Objective(s): Hyperglycemia induces cellular senescence in various body cells, such as vascular endothelial cells. Since the vessels are highly distributed in the body and nourish all tissues, vascular damages cause diabetes complications such as kidney failure and visual impairment. Alpha-mangostin is a xanthone found in mangosteen fruit with protective effects in met...