preparation and characterization of thermoresponsive in-situ forming poloxamer hydrogel for controlled release of nile red-loaded solid lipid nanoparticles. nanoparticles (nps) are cleared rapidly from systemic circulation and do not provide sustained action in most cases. to solve this problem, this investigation introduces an erodible in-situ forming gel system as potential vehicles for prolo...

This paper is an expanded version of lectures given at M.S.R.I. in June of 2008. It provides an introduction to various zeta functions emphasizing zeta functions of a finite graph and connections with random matrix theory and quantum chaos. Section 2. Three Zeta Functions For the number theorist, most zeta functions are multiplicative generating functions for something like primes (or prime ide...

We present a method for calculating the zeta function of a smooth projective variety over a finite field which proceeds by induction on the dimension. Specifically, we outline an algorithm which reduces the problem of calculating a numerical approximation for the action of Frobenius on the middle-dimensional rigid cohomology of a smooth variety, to that of performing the same calculation for a ...

14-3-3 Proteins may function as adapters or scaffold in signal-transduction pathways. We found previously that protein kinase C-zeta (PKC-zeta) can phosphorylate and activate Raf-1 in a signalling complex [van Dijk, Hilkmann and van Blitterswijk (1997) Biochem. J. 325, 303-307]. We report now that PKC-zeta-Raf-1 interaction is mediated by 14-3-3 proteins in vitro and in vivo. Co-immunoprecipita...

The reduction or absence of TCR zeta-chain (zeta) expression in patients with systemic lupus erythematosus (SLE) is thought to be a factor in the pathogenesis of SLE. We previously reported a splice variant of zeta mRNA that lacks the 36-bp exon 7 (zeta mRNA/exon 7(-)) and is accompanied by the down-regulation of zeta protein in T cells from SLE patients. In this study, we show that EX7- mutant...

A simple method is proposed to construct the spectral zeta functions required for calculating the electromagnetic vacuum energy with boundary conditions given on a sphere or on an infinite cylinder. When calculating the Casimir energy in this approach no exact divergencies appear and no renormalization is needed. The starting point of the consideration is the representation of the zeta function...