We recently reported an association between loss in T-cell receptor (TcR) zeta-chain expression and tumor-induced apoptosis of T lymphocytes. In this study, the possibility that zeta-chain serves as a direct substrate for activated caspases was investigated. Here, we report that two DXXD motifs, which are putative recognition sequences for caspase-3-related proteases and are present in the amin...

Insulin stimulates glucose uptake into skeletal muscle tissue mainly through the translocation of glucose transporter 4 (GLUT4) to the plasma membrane. The precise mechanism involved in this process is presently unknown. In the cascade of events leading to insulin-induced glucose transport, insulin activates specific protein kinase C (PKC) isoforms. In this study we investigated the roles of PK...

We examine the validity of the power-law tails of the distributions of stock returns P{R>x} ~ x(-zeta(R)) using trade-by-trade data from three distinct markets. We find that both the negative as well as the positive tails of the distributions of returns display power-law tails, with mutually consistent values of zeta(R) approximately 3 for all three markets. We perform similar analyses of the r...

BACKGROUND AND AIM Impaired expression of the CD3 zeta chain in T cells associated with T cell anergy has been reported in cancer patients. However, few studies have investigated CD3 zeta expression in regional lymph node lymphocytes (LAL) in cancer patients. This study aims to confirm CD3 zeta expression levels by lymph node and peripheral blood lymphocytes (PBL) in gastric cancer patients and...

We study multiple zeta values (MZV’s) over the rational function field $${\mathbb {F}}_q$$ which were introduced by Thakur as analogues of classical Euler. In this paper we affirmatively solve a conjecture Lara Rodriguez and gives full list zeta-like MZV’s weight at most $$q^2$$ depth 2. Further, completely determine all arbitrary depth. Our method is based on criterion derived from Anderson–Th...

Firstly, we prove a functional relation for the Tornheim double zeta function. Using this functional relation, we obtain simple proofs of some known formulas for special values of Tornheim and Euler-Zagier double zeta functions. Secondly, we obtain functional relations for Witten zeta functions by using a double L-values relation. By these functional relations, we obtain new proofs of known res...

DNA polymerase zeta (pol zeta) participates in several DNA transactions in eukaryotic cells that increase spontaneous and damage-induced mutagenesis. To better understand this central role in mutagenesis in vivo, here we report the fidelity of DNA synthesis in vitro by yeast pol zeta alone and with RFC, PCNA and RPA. Overall, the accessory proteins have little effect on the fidelity of pol zeta...

We give an introduction to zeta functions over nite elds, focusing on moment zeta functions and zeta functions of a ne toric hypersurfaces.

We have recently described molecular changes in T cells from tumor-bearing patients that are associated with depressed immune function. The present work investigates changes in T-cell signal transduction proteins including the T-cell receptor-zeta (TCR-zeta) chain and receptor-associated tyrosine kinases in patients with metastatic malignant melanoma. A marked decrease in the expression of the ...