Zebras are members of the horse family. There are three species of zebras: the plains zebra Equus quagga, the Grevy's zebra E. grevyi and the mountain zebra E. zebra. The Grevy's zebra and the mountain zebra are endangered, and hybridization between the Grevy's zebra and the plains zebra has been documented, leading to a requirement for conservation genetic management within and between the spe...

The characterization of genetic aberrations in paraffin-embedded tumor material is impaired by contaminating normal cells. In the present study on the genetic causes of loss of HLA expression in diffuse large B-cell lymphoma (DLBCL), we compared the efficacy of microdissection with flow cytometric sorting of tumor cells. Single-cell suspensions from paraffin-embedded material of 5 DLBCL cases w...

We describe the process of fitting a phenomenological model for the spiking behavior of a zebra-fish neuron using the IPOPT routines described in Wächter and Biegler 2006. These routines provide a computationally efficient methods for estimating parameters in nonlinear differential equations. However, convergence to global solutions is not guaranteed and we describe a number of strategies that ...

Shakespeare advises us that some men are born great, some achieve greatness, and some have greatness thrust upon them. So it is with germ cells. In Drosophila, the very first cells to be formed in the embryo, the pole cells, are germ cells whose descendants have no fate other than to give rise to gametes. In Caenorhabditis and in zebra fish, germ cell determinants present in the egg are asymmet...

A piezoelectric detector with a cylindrical shape is investigated for photoacoustic section imaging. Images are acquired by rotating a sample in front of the cylindrical detector. With its length exceeding the size of the imaging object, it works as an integrating sensor and therefore allows reconstructing section images with the inverse Radon transform. Prior to the reconstruction the Abel tra...

Stefan Schulte-Merker has been working with zebra®sh for over ten years and was involved in a number of genetic screens. He was also part of a team that produced a ®rst-generation map of the `Goodfellow panel' of radiation hybrids, which was intended to help in the cloning of the mutated genes. He is currently Head of Fish Genetics at Artemis Pharmaceuticals, in TuÈbingen, who are in the proces...