•Hydroxyurea downregulates proliferation gene sets in PV HSC/MPPs but not CMP/MEPs.•Twenty-nine of 57 solute carrier transporters are expressed and CMP/MEPs.•The HU transporter OCTN1 is upregulated untreated patients.•The diffusion facilitator UTB downregulated compared with CMP/MEPs. Polycythemia vera (PV) a myeloproliferative neoplasm marked by hyperproliferation the myeloid lineages presence...

•A single-cell immune atlas of patients with BD quetiapine and valproate treatment•Decreased population pro-inflammatory cells observed•Reduced ribosomal function detected in B T after treatment•Myloid-mediated signaling pathway decreased treatment Bipolar disorder (BD) is a common mental characterized by manic depressive episodes. Mood disorders have been associated dysfunction. The combinatio...

Benzoxathiole derivatives have been used in the treatment of acne and have shown cytostatic, antipsoriatic, and antibacterial properties. However, little is known about the molecular basis for these pharmacological properties, although nuclear factor (NF)B activation is closely linked to inflammation and cell proliferation. Here, we demonstrate that the novel small-molecule benzoxathiole 6,6-di...

More than 90% of pa tients with dementia will eventually develop behavioral and psychological symptoms of dementia, which in clude agitation, psychosis, and mood disorders. The Vancouver Coastal Health Authority has recently produced a guideline for the assessment, nonpharmacological treatment, and pharmacological treatment of ag gression and agitation in patients with dementia in acute or resi...

Socio-emotional dysfunction is a core feature of bipolar disorder (BD) across the lifespan. Recent evidence indicates associations between this atypical functioning and the presence of neurally-based anomalies. This article critically reviews the literature on two types of core socioemotional skills that may represent endophenotypes for BD, with a focus on differences between individuals with B...