BACKGROUND The potential medical applications of nanomaterials are shaping the landscape of the nanobiotechnology field and driving it forward. A key factor in determining the suitability of these nanomaterials must be how they interface with biological systems. Single walled carbon nanotubes (CNT) are being investigated as platforms for the delivery of biological, radiological, and chemical pa...

PURPOSE To determine the maximum tolerated dose of combined therapy using an yttrium-90-labeled anti-carcinoembryonic antigen (CEA) antibody with gemcitabine in patients with advanced CEA-producing solid tumors. EXPERIMENTAL DESIGN The chimeric human/murine cT84.66 is an anti-CEA intact IgG1, with high affinity and specificity to CEA. This was given at a fixed yttrium-90-labeled dose of 16.6 ...

In this thesis, we report on a process to obtain yttrium oxide nanosized particles doped with ytterbium and a sintering method that leads to transparent polycrystalline ceramics. First, nano-powder of yttria was fabricated from a precursor with transient morphology, i.d. yttrium hydroxynitrate platelets that decompose into spherical yttria nano-particles during calcination. The influence of dif...

A new family of Y(4)/M(2) and Y(5)/M heterobimetallic rare-earth-metal/d-block-transition-metal-polyhydride complexes has been synthesized. The reactions of the tetranuclear yttrium-octahydride complex [{Cp''Y(μ-H)(2)}(4)(thf)(4)] (Cp'' = C(5)Me(4)H, 1-C(5)Me(4)H) with one equivalent of Group-6-metal-pentahydride complexes [Cp*M(PMe(3))H(5)] (M = Mo, W; Cp* = C(5)Me(5)) afforded pentanuclear he...

Numerous bulk crystalline materials exhibit attractive nonlinear and luminescent properties for classical and quantum optical applications. A chip-scale platform for high quality factor optical nanocavities in these materials will enable new optoelectronic devices and quantum light-matter interfaces. In this article, photonic crystal nanobeam resonators fabricated using focused ion beam milling...

Recovery and reuse of materials is important for a circular economy. In recent years the recovery of critical metals from end-of-life products has received increased attention. Various streams, e.g. permanent magnets, nickel metal hydride batteries and fluorescent lamps are considered targets for the recovery of rare earth elements (REEs). The last can be a source of up to six different REEs: e...

Chiral alkyl or amido yttrium complexes were prepared from N-silyl- or N-cyclopentyl-substituted binaphthylamido ligands. According to the synthetic procedure, these complexes could be obtained in their neutral form or as heterobimetallic complexes in the presence of 1 equiv. LiCl. These new species were characterized by IR and NMR spectroscopies, elemental analyses and some of them by X-ray di...