Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), such as gefitinib, remains a major problem in non-small cell lung cancer (NSCLC) treatment. Increased activation of AXL has been identified as a novel mechanism for acquired resistance to EGFR-TKIs in NSCLC treatment. However, the cause of uncontrolled AXL expression is not fully understood. Here, we...

Histone acetylation is one of the key chromatin modifications that control gene transcription during development and tumorigenesis. Recently, it was reported that the histone deacetylase inhibitor, Trichostatin A (TSA), induces growth arrest and apoptosis in tumors. However, the molecular mechanisms responsible for its antitumor effects are not cl...

It is well known that the G(n, p) model of random graphs undergoes a dramatic change around p = 1 n . It is here that the random graph, almost surely, contains cycles, and here it first acquires a giant (i.e., order Ω(n)) connected component. Several years ago, Linial and Meshulam introduced the Yd(n, p) model, a probability space of n-vertex d-dimensional simplicial complexes, where Y1(n, p) c...

4 Xavier Bonnet, Alain Fizesan, Catherine Louise Michel 5 6 7 1. CEBC-CNRS, 79360 Villers en Bois, France 8 9 Correspondance : Xavier Bonnet ; Tel +33 549 097 879 ; Fax +33 549 096 111 ; email 10 [email protected] 11 12 13 Submitted for consideration in Journal of Experimental Biology 14 15 16

We report on a partially circular X-ray surface brightness discontinuity found at about 55 kpc from the centre of Abell 2199 with Chandra X-ray observatory observations. Unlike cold fronts found in other clusters, the feature shows no significant temperature change across it but has an apparent density jump. We therefore identify it as a weak isothermal shock associated with the central AGN and...

These are lecture notes not in final form and will be continuously edited and/or corrected (as I am sure it contains many typos). Please let me know if you find any typo/mistake. Also, I am posting short descriptions of these notes (together with the open problems) on my Blog, see [Ban15a]. Concentration and large deviations inequalities are among the most useful tools when understanding the pe...

Purpose. The purpose of our study was to examine the relationships between pathological patterns and self-rated quality of life (QoL). Methods. A total of 426 Korean subjects participated in this study (male : female = 154 : 272). The subjects were asked to complete Yin Deficiency (YD), Qi Deficiency (QD), Food Stagnation (FS), Blood Stasis (BS), Phlegm, and Seven Emotions Impairment (SEI) patt...

Metformin is a biguanide widely prescribed as an antidiabetic drug for type 2 diabetes mellitus patients. The purpose of the present study was to observe the effects of the new metformin derivative, HL156A, on human oral cancer cell and to investigate its possible mechanisms. It was observed that HL156A significantly decreased FaDu and YD-10B cell viability and colony formation in a dose-depend...

This article presents the process used to develop a set of statewide positive youth development (YD) outcome indicators to complement existing adolescent well-being indicators in New York State (NYS). Intended uses included program and community-, county-, and state-level planning; grant writing; evaluation; and outcome monitoring in coordination with national YD-oriented initiatives. A common ...