نتایج جستجو برای: yap gene

تعداد نتایج: 1145607  

2016
Jia Wang James Sinnett-Smith Jan V. Stevens Steven H. Young Enrique Rozengurt

We examined the regulation of Yes-associated protein (YAP) localization, phosphorylation, and transcriptional activity in intestinal epithelial cells. Our results show that stimulation of intestinal epithelial IEC-18 cells with the G protein-coupled receptor (GPCR) agonist angiotensin II, a potent mitogen for these cells, induced rapid translocation of YAP from the nucleus to the cytoplasm (wit...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2017
Koji Taniguchi Toshiro Moroishi Petrus R de Jong Michal Krawczyk Britta Moyo Grebbin Huiyan Luo Rui-Hua Xu Nicole Golob-Schwarzl Caroline Schweiger Kepeng Wang Giuseppe Di Caro Ying Feng Eric R Fearon Eyal Raz Lukas Kenner Henner F Farin Kun-Liang Guan Johannes Haybaeck Christian Datz Kang Zhang Michael Karin

Loss of tumor suppressor adenomatous polyposis coli (APC) activates β-catenin to initiate colorectal tumorigenesis. However, β-catenin (CTNNB1) activating mutations rarely occur in human colorectal cancer (CRC). We found that APC loss also results in up-regulation of IL-6 signal transducer (IL-6ST/gp130), thereby activating Src family kinases (SFKs), YAP, and STAT3, which are simultaneously up-...

2011
Lin Ge Matthew Smail Wenxia Meng Yu Shyr Fei Ye Kang-Hsien Fan Xiaohong Li Hong-Mei Zhou Neil A. Bhowmick

INTRODUCTION Yes-associated protein (YAP) is considered an oncogene found amplified in multiple tumors, including head and neck squamous cell carcinoma (HNSCC). However, the role for YAP expression in HNSCC is not understood. Based on the central role of YAP in the hippo pathway, we tested if YAP was associated with the stage of HNSCC progression and metastatic potential. METHODS To determine...

Journal: :Cell 2006
Lars Zender Mona S. Spector Wen Xue Peer Flemming Carlos Cordon-Cardo John Silke Sheung-Tat Fan John M. Luk Michael Wigler Gregory J. Hannon David Mu Robert Lucito Scott Powers Scott W. Lowe

The heterogeneity and instability of human tumors hamper straightforward identification of cancer-causing mutations through genomic approaches alone. Herein we describe a mouse model of liver cancer initiated from progenitor cells harboring defined cancer-predisposing lesions. Genome-wide analyses of tumors in this mouse model and in human hepatocellular carcinomas revealed a recurrent amplific...

2017
Wen-Qian Zhang Yu-Yuan Dai Ping-Chih Hsu Hui Wang Li Cheng Yi-Lin Yang Yu-Cheng Wang Zhi-Dong Xu Shu Liu Geraldine Chan Bin Hu Hui Li David M Jablons Liang You

Malignant mesothelioma is an aggressive cancer that is resistant to current therapy. The poor prognosis of mesothelioma has been associated with elevated Yes-associated protein (YAP) activity. In this study, we evaluated the effect of targeting YAP in mesothelioma. First, we comprehensively studied YAP activity in five mesothelioma cell lines (211H, H2052, H290, MS-1 and H2452) and one normal m...

2017
Myung-Giun Noh Sung Sun Kim Eu Chang Hwang Dong Deuk Kwon Chan Choi

BACKGROUND Yes-associated protein (YAP) in the Hippo signaling pathway is a growth control pathway that regulates cell proliferation and stem cell functions. Abnormal regulation of YAP was reported in human cancers including liver, lung, breast, skin, colon, and ovarian cancer. However, the function of YAP is not known in prostate adenocarcinoma. The purpose of this study was to investigate the...

Journal: :Development 2016
Zhihui Huang Jinxia Hu Jinxiu Pan Ying Wang Guoqing Hu Jiliang Zhou Lin Mei Wen-Cheng Xiong

‪YAP (yes-associated protein), a key transcriptional co-factor that is negatively regulated by the Hippo pathway, is crucial for the development and size control of multiple organs, including the liver. However, its role in the brain remains unclear. Here, we provide evidence for YAP regulation of mouse neocortical astrocytic differentiation and proliferation. YAP was undetectable in neurons, b...

Journal: :American journal of cancer research 2016
Chao Wang Xiaoyong Zhu Weiwei Feng Yinhua Yu Kangjin Jeong Wei Guo Yiling Lu Gordon B Mills

Yes-associated protein (YAP), the central mediator of Hippo pathway, not only regulates a diversity of cellular processes during development but also plays a pivotal role in tumorigenesis. YAP is overexpressed in many types of human cancers with its expression level being associated with patient outcomes. Thus, inhibiting YAP function could provide a novel therapeutic approach. Verteporfin, a p...

Journal: :Journal of applied physiology 2016
Brendan M Gabriel D Lee Hamilton Annie M Tremblay Henning Wackerhage

The ubiquitous transcriptional coactivators Yap (gene symbol Yap1) and Taz (gene symbol Wwtr1) regulate gene expression mainly by coactivating the Tead transcription factors. Being at the center of the Hippo signaling network, Yap and Taz are regulated by the Hippo kinase cassette and additionally by a plethora of exercise-associated signals and signaling modules. These include mechanotransduct...

Journal: :Circulation research 2015
Jifen Li Erhe Gao Alexia Vite Roslyn Yi Ludovic Gomez Steven Goossens Frans van Roy Glenn L Radice

RATIONALE Shortly after birth, muscle cells of the mammalian heart lose their ability to divide. Thus, they are unable to effectively replace dying cells in the injured heart. The recent discovery that the transcriptional coactivator Yes-associated protein (Yap) is necessary and sufficient for cardiomyocyte proliferation has gained considerable attention. However, the upstream regulators and si...

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