نتایج جستجو برای: xrcc2
تعداد نتایج: 204 فیلتر نتایج به سال:
We prove that the largest eigenvalues of the beta ensembles of random matrix theory converge in distribution to the low-lying eigenvalues of the random Schrödinger operator − d dx2 + x+ 2 √ β bx restricted to the positive half-line, where b ′ x is white noise. In doing so we extend the definition of the Tracy-Widom(β) distributions to all β > 0, and also analyze their tails. Last, in a parallel...
Highly penetrant, but rare, mutations in genes involved in double-strand break repair (i.e., BRCA1 and BRCA2) are associated with a risk for breast cancer of 40% to 65% by age 70 years (1, 2). Polymorphisms in other double-strand break repair genes are thought to contribute to the risk for the disease, either independently or through modifying the risk associated with rare mutations. This study...
Genetic polymorphisms in DNA repair genes may induce individual variations in DNA repair capacity, which may in turn contribute to the risk of cancer developing. Homologous recombination repair (HRR) plays a critical role in maintaining chromosomal integrity and protecting against carcinogenic factors. The aim of the present study was to evaluate the relationship between prostate cancer risk an...
The five RAD51 paralogs (RAD51B, RAD51C, RAD51D, XRCC2, and XRCC3) are required in mammalian cells for normal levels of genetic recombination and resistance to DNA-damaging agents. We report here that RAD51D is also involved in telomere maintenance. Using immunofluorescence labeling, electron microscopy, and chromatin immunoprecipitation assays, RAD51D was shown to localize to the telomeres of ...
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