Alcohol withdrawal syndrome is characterized by hyperactivity of the nervous system. This hyperactivity represents the brain's attempt to function normally despite the inhibitory effect of chronic alcohol consumption. The syndrome manifests when alcohol consumption ceases. Experimental, clinical, and genetic research have linked the development of withdrawal to alterations in the sensitivity of...

The increasing use of buprenorphine among drug dependent subjects demands systematic enquiry into the clinical profile of buprenorphine withdrawal. Six male buprenorphine dependent (parenteral) subjects were observed for opiate withdrawal over a two week period. The onset of withdrawal occurred 48 hours after the last dose, peaked around the third day and lasted up to ten days. The withdrawals ...

Four term neonates presented with symptoms such as jitteriness and necrotising enterocolitis after paroxetine exposure in utero.

FEW WHO HAVE WITNESSED the propranolol withdrawal phenomenon would deny its existence. The syndrome, which comprises the development of ventricular arrhythmias, severe angina, myocardial infarction and even death soon after sudden cessation of propranolol therapy, was first described in a series of case reports.' Perhaps the most convincing evidence was obtained by Miller et al.,6 who noted a 5...

Dual-action antidepressants serotonin-norepinephrine reuptake inhibitors (SRNIs) are widely used to treat depression. Owing to its efficiency and safety, venlafaxine holds a prominent place in this group of depressants. Abrupt venlafaxine discontinuation involves a high risk of withdrawal syndrome. Mechanism of its development is similar to that of selective serotonin reuptake inhibitors (SSRIs...