1 Whole Genome Sequencing 2

To the editor: While the speed and cost of genome sequencing has improved dramatically, the task of interpreting gene sequences for clinical purposes remains challenging [1-4]. Thousands of investigations into the pathogenicity of genetic variants have been completed and reported in peerreviewed studies – however – which studies should be reviewed for each patient genome? The task of matching s...

Whole genome sequencing of disease animal models together with population genetics methodology is a powerful technology for deciphering new variations which associated with disease phenotypes. Here we show our studies on camel, dog, and rabbit. Whole genome sequencing data were generated from those animals, and then population genetics methodology was used in dealing with these whole genome seq...

Step One – DNA sample preparation; Step Two – Proprietary process to load DNA sample onto beads; Step Three – Sequencing DNA on Genome Sequencer FLX instrument; and Step Four –Analysis of the genome

Grazing businesses with a proportion of native grassland may face the choice of reassigning the rights to use an area of native grassland to the public. In analysing this choice it is important to establish the future situation of the farm business with and without the area of land in question, including the possibility of further development of production capacity on other areas of the farm. T...

Should the results of whole genome sequencing research be disclosed to participants, in particular when the results have uncertain or indeterminate phenotypic consequences? This controversial question is considered in light of one author's (J.L.) experience as a geneticist who recently had his own genome sequenced.

Our molecular understanding of glioma has undergone a sea change over the last decade. In this review, we discuss two recent articles that employed whole genome sequencing to subclassify gliomas vis-à-vis known molecular alterations. We further discuss the relevance of these findings vis-à-vis current treatment paradigms.

Enterobacter ludwigii strain EN-119(T) is the type strain of E. ludwigii, which belongs to the E. cloacae complex (Ecc). This strain was first reported and nominated in 2005 and later been found in many hospitals. In this paper, the whole genome sequencing of this strain was carried out. The total genome size of EN-119(T) is 4952,770 bp with 4578 coding sequences, 88 tRNAs and 10 rRNAs. The gen...