نتایج جستجو برای: white matter hyperintensitiess
تعداد نتایج: 368003 فیلتر نتایج به سال:
Structural delineation and assignment are the fundamental steps in understanding the anatomy of the human brain. The white matter has been structurally defined in the past only at its core regions (deep white matter). However, the most peripheral white matter areas, which are interleaved between the cortex and the deep white matter, have lacked clear anatomical definitions and parcellations. We...
The objectives of this study were to evaluate the correlations of the volumes of the gray matter and white matter with age, and the correlations of the tissue probabilities of the gray matter and white matter with age and several cerebrovascular risk factors. We obtained magnetic resonance (MR) images of the brain and clinical information from 769 normal Japanese subjects. We processed the MR i...
Cigarette smoking doubles the risk of dementia and Alzheimer's disease. Various pathophysiological pathways have been proposed to cause such a cognitive decline, but the exact mechanisms remain unclear. Smoking may affect the microstructural integrity of cerebral white matter. Diffusion tensor imaging is known to be sensitive for microstructural changes in cerebral white matter. We therefore cr...
Expansion of the cortical gray matter in evolution has been accompanied by an even faster expansion of the subcortical white matter volume and by folding of the gray matter surface, events traditionally considered to occur homogeneously across mammalian species. Here we investigate how white matter expansion and cortical folding scale across species of rodents and primates as the gray matter ga...
Recent research has suggested the use of white matter (WM) reference regions for longitudinal tau-PET imaging. However, tau tracers display affinity β-sheet structure formed by myelin, and thus WM lesions might influence tracer retention. Here, we explored whether tau-sensitive [18F]flortaucipir shows reduced retention in hyperintensities (WMH) how this changes over time. We included 707 partic...
BACKGROUND Until more recently, most studies have examined the changes in brain gray matter in major depressive disorder (MDD) with less studies focusing on understanding white matter pathology in MDD. Studies of brain white matter volume changes, connectivity disruptions, as well as genetic factors affecting myelination can throw light on the nature of white matter abnormalities underpinning M...
MicroRNA expression profiles of patients with multiple sclerosis (MS) have revealed differences from healthy controls both in cells from the peripheral circulation and in specimens from white matter lesions. Here, we studied differences in microRNA expression and in their predicted mRNA targets in white and grey matter lesions of patients with MS as compared with white and grey matter brain tis...
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