In the metazoan replication timing program, clusters of replication origins located in different subchromosomal domains fire at different times during S phase. We have used Xenopus laevis egg extracts to drive an accelerated replication timing program in mammalian nuclei. Although replicative stress caused checkpoint-induced slowing of the timing program, inhibition of checkpoint kinases in an ...

A timing recovery architecture and its CMOS implementation are described for a noise-predictive decisionfeedback equalizer (NPDFE). The 0.5μm CMOS prototype includes timing recovery and the NPDFE and operates at 160Mbps. The timing recovery blocks dissipate 27mW from 3.3V, occupy 0.2 mm, and achieve a rms jitter of 50 ps, which is 0.8% of a bit period.