The year 2014 has become a remarkable year for heart failure. A bad start was caused by the publication of TOPCAT, showing that spironolactone did not prove to be beneficial for the treatment of patients with heart failure and preserved ejection fraction (HFpEF). Nevertheless, further insights in the study yields a few bright spots, and treatment with spironolactone might still be considered in...

BACKGROUND Controlled-rate freezing of ovarian cortical tissue for preservation of fertility among young women facing chemo- or radio-therapy is a widely accepted procedure. To improve the method for cryopreservation of ovarian tissue, particularly the stroma, we carried out a systematic comparison of vitrification versus slow programmed freezing. METHODS Ovarian tissue from 20 women, donated...

The present study was carried out to investigate the status of health and disease, and their impact on shrimp broodstock (Litopenaeus vannamei) in Khouzestan Province (Choeibde Area) in the south of Iran. From March 2012 until April 2013, about 140 broodstock and 5000 postlarvae (PLs) were collected from hatcheries and grow out farms. Clinical signs of samples were documented in take history fo...

Although telomere length is genetically determined, mouse embryonic stem (ES) cells with telomeres of twice the normal size have been generated. Here, we use such ES cells with 'hyper-long' telomeres, which also express green fluorescent protein (GFP), to generate chimaeric mice containing cells with both hyper-long and normal telomeres. We show that chimaeric mice contain GFP-positive cells in...

BACKGROUND Livers derived from donation after circulatory death (DCD) are increasingly accepted for transplantation. However, DCD livers suffer additional donor warm ischemia, leading to biliary injury and more biliary complications after transplantation. It is unknown whether oxygenated machine perfusion results in better preservation of biliary epithelium and the peribiliary vasculature. We c...

Background: There has been conflicting data on whether Nursing Magnet Hospitals (NMH) provide better care. Methods: NMH in the Southwest USA (Arizona, California, Colorado, Hawaii, Nevada, and New Mexico) were compared to hospitals not designated as NMH using the Centers for Medicare and Medicaid (CMS) hospital compare star designation. Results: NMH had higher star ratings than non-NMH hospital...