population-based genetic association studies have proven to be a powerful tool in identifying genes implicated in many complex human diseases that have a huge impact on public health. an essential quality control step in such studies is to undertake hardy-weinberg equilibrium (hwe) calculations. deviations from hwe in the control group may reflect important problems including selection bias, po...

Modeling and detecting nonallelic (epistatic) effects at multiple quantitative trait loci (QTL) often assume that the study population is in zygotic equilibrium (i.e., genotypic frequencies at different loci are products of corresponding single-locus genotypic frequencies). However, zygotic associations can arise from physical linkages between different loci or from many evolutionary and demogr...

This paper considers the random simulation of genotypes from relative pairs using R. After Hardy-Weinberg equilibrium law is introduced systematically, joint probability distributions general are studie. Then ITO method was discussed in detail. Based on theo ry described above, computer program for written According to these R codes, can be easily generated randomly.

four saudi arabian indigenous sheep populations including najdi, hbsi, arb, and naemi were genotyped for 16 microsatellite markers recommended by the food and agriculture organization (fao). this study aims to provide information on the genetic structure of the breeds analyzed and give indications and proposals for the cross breeding program. all loci were polymorphic in all populations and loc...