BACKGROUND Most of bayesian pharmacokinetic studies and the influence of clinical variables have been carried out in adults. PURPOSE The aim was to estimate population-based pharmacokinetic of valproic acid (VPA) and to determine the effect of treatment and additional disease on its performance in children with epilepsy. MATERIAL AND METHODS For the study steady-state serum concentrations o...

Responses of growth hormone (GH) release to synthetic human growth hormone-releasing factor (hGRF)-44-NH2 analogs were determined, and the GH-releasing potency based on dose per kg of body weight (bw) was compared with that of hGRF-44-NH2 in female dairy calves. Four- and 12-month-old calves were injected intravenously with 0.25 microgram of hGRF-44-NH2 or its analogs per kg of bw. Blood sample...

Background: Globally, neonatal deaths constitute 44% of all in less than 5 years age group .The concept SNCU is based on the learning from “Purulia model”. This research study was undertaken, to assess profile sick newborns admitted SNCU.Methods The investigators analyzed this data and establish morbidity Hamirpur 2019.Results: Total 422 were 197 (46.7%) females 225 (53.3%) males. Out these 381...

BACKGROUND Low-carbohydrate diets, due to their potent antihyperglycemic effect, are an intuitively attractive approach to the management of obese patients with type 2 diabetes. We previously reported that a 20% carbohydrate diet was significantly superior to a 55-60% carbohydrate diet with regard to bodyweight and glycemic control in 2 groups of obese diabetes patients observed closely over 6 ...

Liraglutide (LIRA) treatment is associated with the dose-dependent reduction of weight. Higher doses are more effective than lower doses, although higher doses are also more poorly tolerated. Metformin may enhance the weight-lowering potential of LIRA via the stimulatory modulation of incretin in addition to its direct beneficial effects in PCOS. The aim of the present study was to evaluate whe...

Background: Increased physical activity may be advantageous for weight loss.Objective: We investigated the effects of an energy-restricted diet with and without moderate walking on body weight, body composition, resting energy expenditure (REE), and endocrine and cardiometabolic risk variables in overweight and obese participants.Methods: A 12-wk, randomized, 2-arm, parallel, controlled, energy...

http://bmj.com/cgi/content/full/324/7336/539 Updated information and services can be found at: These include: Data supplement http://bmj.com/cgi/content/full/324/7336/539/DC1 "List of DLS's potential conflicts" References http://bmj.com/cgi/content/full/324/7336/539#otherarticles 3 online articles that cite this article can be accessed at: http://bmj.com/cgi/content/full/324/7336/539#BIBL This ...

OBJECTIVE To objectively and critically assess body mass index and to propose alternatives for relating body weight and height that are evidence-based and that eliminate or reduce the limitations of the body mass index. METHODS To analyze the relations involving weight and height, we used 2 databases as follows: 1) children and adolescents from Brazil, the United States, and Switzerland; and ...