The role of high serum and tissue levels of unconjegated bilirubin in the pathogenesis of the impaired urinary concentrating ability was investigated in homozygous (jj) Gunn rats with the congenital absence of hepatic glucuronyl transferase. Continuous phototherapy with blue fluorescent lights at a wave length of 460 nm or oral cholestyramine feeding or both reduced serum levels of unconjugated...

The purpose of this study was to answer the question as to whether the food preferences of the young are dependent on the social influences or not. The experiments were conducted on female cats bearing electrodes implanted in the mid-lateral hypothalamus, and their weanling kittens. Each mother was given a self-stimulation test; the mothers which learned to press a lever for the hypothalamic st...

1. The intraperitoneal injection of N-methyl-N-nitrosourea (100mg/kg) caused a partial inhibition of protein synthesis in several organs of the rat, the maximum effect occurring after 2-3h. 2. In the liver the inhibition of protein synthesis was paralleled by a marked disaggregation of polyribosomes and an increase in ribosome monomers and ribosomal subunits. No significant breakdown of polyrib...

Norway rat pups, 15 days of age and older, huddle preferentially with members of their own species. This normal filial response can be reassigned, however, by altering the olfactory characteristics of the mother. The present series of experiments was designed to isolate those aspects of maternal stimulation that establish the filial huddling preferences of rat pups. Results of two-choice huddli...

OBJECTIVE We demonstrated previously that chronic maternal micronutrient restriction altered the body composition in rat offspring and may predispose offspring to adult-onset diseases. Chromium (Cr) regulates glucose and fat metabolism. The objective of this study is to determine the long-term effects of maternal Cr restriction on adipose tissue development and function in a rat model. RESEAR...

The effect of dietary undegraded carrageenan (Viscarin 402) on colon carcinogenesis was studied in female inbred F344 rats. Weanling rats were fed semipurified diets containing 0 or 15% undegraded carrageenan. At 7 weeks of age, all animals except controls were given azoxymethane (AOM) s.c. at a dose rate of 8 mg/kg body weight per week for 10 weeks or methylnitrosourea (MNU) intrarectally at a...

The anti-diabetic activity of camel milk in type 1 diabetics is attributed to the significant amounts of insulin / insulin like activity present in it. However, evidence for the anti-diabetic activity of camel milk is scanty and equivocal. This study evaluated the anti-hyperglycemic effect of camel milk using drug (Streptozotocin) and diet (high sucrose) induced rat models for diabetes / insuli...

Haemophilus influenzae requires an exogenous heme source for aerobic growth in vitro. Hemoglobin or hemoglobin-haptoglobin satisfies this requirement. Heme acquisition from hemoglobin-haptoglobin is mediated by proteins encoded by hgp genes. Both Hgps and additional proteins, including those encoded by the hxu operon, provide independent pathways for hemoglobin utilization. Recently we showed t...

Nontypeable Haemophilus influenzae strain INT1 was isolated from the blood of a young child with clinical signs of meningitis following acute otitis media. No immunologic or anatomic predisposition of this child for invasive bacterial infection with an unusual organism was documented. Sensitive ELISA proved the absence of intra- or extracellular capsular polysaccharide production by INT1 and So...