In a previous study we reported the presence of a large conductance K(+) channel in the membrane of endoplasmic reticulum (ER) from rat hepatocytes. The channel open probability (Po) appeared voltage dependent and reached to a minimum 0.2 at +50 mV. Channel activity in this case was found to be totally inhibited at ATP concentration 2.5 mM, glibenclamide 100 µM and tolbutamide 400 µM. Existing ...

The double lipid bilayer of the nuclear envelope (NE) remains intact during closed mitosis. In the fission yeast Schizosaccharomyces pombe, the intranuclear mitotic spindle has envelope-embedded spindle pole bodies (SPB) at its ends. As the spindle elongates and the nucleus divides symmetrically, nuclear volume remains constant but nuclear area rapidly increases by 26%. When Ran-GTPase function...

BACKGROUND Treatment of pediatric type I open fractures is controversial. Centers have reported good success with emergency room (ER) treatment of low-energy (type I) open pediatric fractures. The purpose of this study was to ascertain the treatment preferences of pediatric orthopaedic surgeons for type I open fractures. We hypothesize that surgeons will have different treatment protocols and p...

A condition is identified which guarantees that the coinvariants of a coaction of a Hopf algebra on an algebra form a subalgebra, even though the coaction may fail to be an algebra homomorphism. A Hilbert Theorem (finite generation of the subalgebra of coinvariants) is obtained for such coactions of a cosemisimple Hopf algebra. This is applied for two coactions α, β : A → A⊗O, where A is the co...

The purpose of this paper is to introduce and study the concepts of intuitionistic fuzzy weakly generalized closed set and intuitionistic fuzzy weakly generalized open set in intuitionistic fuzzy topological space. We investigate some of their properties. Also we study the application of intuitionistic fuzzy weakly generalized closed set namely intuitionistic fuzzy wT1/2 space and intuitionisti...

This paper is devoted to the study of intuitionistic fuzzy topological spaces. In this paper an intuitionistic fuzzy regular weakly generalized closed set and intuitionistic fuzzy regular weakly generalized open set are introduced. Some of its properties are studied. Also we have provided some applications of intuitionistic fuzzy weakly generalized closed set namely intuitionistic fuzzy rwT1/2 ...

The ubiquitous inositol 1,4,5-trisphosphate (InsP(3)) receptor (InsP(3)R) channel, localized primarily in the endoplasmic reticulum (ER) membrane, releases Ca(2+) into the cytoplasm upon binding InsP(3), generating and modulating intracellular Ca(2+) signals that regulate numerous physiological processes. Together with the number of channels activated and the open probability of the active chan...

The function of estrogen in breast cancer proliferation and progression is likely to be due to the expression of a repertoire of genes regulated by estrogen receptor (ER). Using suppression subtractive hybridization, we have isolated a set of 14 estrogen-responsive genes that was differentially expressed in MCF7 cells stimulated by beta-estradiol as compared with unstimulated cells. Tamoxifen r...

This study studies the role of hidden curriculum on educational function of students in 2011-2012. It also studies the hidden curriculum (social setting) on educational function among high- school students in Nayshabour. This research is descriptive and inferential. It also uses Halpean craft questionnaire and the validity shows 88%. 290 students were selected. Social settings of high schools i...

The purpose of this paper is to introduce and study the concepts of intuitionistic fuzzy almost weakly generalized closed mappings and intuitionistic fuzzy almost weakly generalized open mappings in intuitionistic fuzzy topological space. Some of their properties are explored.