Tamoxifen is administered for estrogen receptor positive (ER+) breast cancers, but it can induce uterine endometrial cancer and non-alcoholic fatty liver disease (NAFLD). Importantly, ten years of tamoxifen treatment has greater protective effect against ER+ breast cancer than five years of such treatment. Tamoxifen was also approved by the FDA as a chemopreventive agent for those deemed at hig...

a one-sided ideal of a ring has the insertion of factors property (or simply, ifp) if implies r for . we say a one-sided ideal of has the weakly ifp if for each , implies , for some non-negative integer . we give some examples of ideals which have the weakly ifp but have not the ifp. connections between ideals of which have the ifp and related ideals of some ring extensions are also shown.

In a context of classi cation, we propose to use conditional mutual information to select a family of binary features which are individually discriminating and weakly dependent. We show that on a task of image classi cation, despite its simplicity, a naive Bayesian classi er based on features selected with this Conditional Mutual Information Maximization (CMIM) criterion performs as well as a c...

BACKGROUND In human breast cancer, a growth status switched from estrogen-dependent to growth factor-dependent is a critical step during development of acquired tamoxifen resistance. However, the molecular mechanisms underlying this switch remain poorly understood. The Wilms' tumor suppressor gene, WT1, encodes a zinc-finger protein WT1 that functions as a transcription regulator. High levels o...

Holomeric estrogen receptor (ER) prepared from ovariectomized mouse uteri displays heterogeneous electrophoretic mobility when analyzed by NaDodSO4/PAGE. ER derived from nuclei (ERn) appears as a closely spaced doublet having apparent molecular masses of 66.4 and 65 kDa, while ER from the cytosolic compartment (ERc) has a single band of 65 kDa. Both partially purified ERc and the 8S form of una...

Background. It is unclear whether the clinical use of tibial rotation to measure the strength of the medial hamstrings and lateral hamstrings in isolation is based on sound scientific evidence or is simply based on anatomical features. Objectives. To verify the appropriateness of tibial rotation for isolation of the medial hamstrings and lateral hamstrings, the participants performed neutral r...

Primary-like and weakly primary-like submodules are two new generalizations of primary ideals from rings to modules. In fact, the class of primary-like submodules of a module lie between primary submodules and weakly primary-like submodules properly.  In this note, we show that these three classes coincide when their elements are submodules of a multiplication module and satisfy the primeful pr...

in the present paper, we rst modify the concepts of weakly fuzzy boundedness, strongly fuzzy boundedness, fuzzy continuity, strongly fuzzy continuity and weakly fuzzy continuity. then, we try to nd some relations by making a comparative study of the fuzzy norms of linear operators.