Epithelial ovarian cancer (EOC) is the most lethal and aggressive gynecological malignancy, and abnormal cellular metabolism significantly contributes to cancer onset and progression. Here, we report that miR-29b negatively regulates AKT2/AKT3 expression, causing HK2/PKM2 downregulation and leading to a decreased Warburg effect and slowed ovarian cancer progression. Compared to normal ovaries, ...

At present, there is no treatment option available for COVID-19 condition and most importantly the underlying pathophysiology in not known. In this article, I had given a viewpoint that explains based on it proposed options COVID-19. propose adrenergic storm-induced Warburg effect (aerobic glycolysis) may be mechanism condition. alpha1 blockers early phase beta-adrenergic late of to inhibit sto...

One of the most common abnormalities of cancer cells is their predilection to engage in a high rate of glycolysis despite the continued availability of oxygen. First described by Otto Warburg, this phenomenon of aerobic glycolysis (or the Warburg effect) has recently been proposed to result from cancer-associated alterations in signal transduction pathways. In this issue of The EMBO Journal, Pa...

18F-fluorodeoxyglucose (18F-FDG) positron emission tomography has become an important tool for detection, staging and management of many types of cancer. Oncology application of 18F-FDG bases on the knowledge that increase in glucose demand and utilization is a fundamental features of cancer. Pasteur effect, Warburg effect and reverse Warburg effect have been used to explain glucose metabolism ...

During the proliferation and metastasis, the tumor cells prefer glycolysis (Warburg effect), but its exact mechanism remains largely unknown. In this study, we demonstrated that phosphoglycerate kinase 1 (PGK1) is an important enzyme in the pathway of metabolic glycolysis. We observed a significant overexpression of PGK1 in hepatocellular carcinoma tissues, and a correlation between PGK1 expres...

Editorial Proliferating cells such as tumor cells have increased metabolic demands that include ATP, NADPH, lipids, proteins, and nucleotides to allow for a tumor cell to divide into two daughter cells [1]. Tumor cells reprogram their cell metabolism to sustain the increased metabolic demands of cell proliferation. Historically, much attention has focused on glycolysis as the central metabolic ...

The investigations of Warburg in 1921 on the action of narcotics on cell respiration led to the formulation of his general theory of narcosis, according to which the action of a narcotic is attributed to its specific ability to occupy the vital surfaces of the cell structures, thereby displacing the adsorbed nutritive substances and important oxidative enzymes (1). The occasional observations o...