Acarboxyprothrombin (protein induced by vitamin K absence or antagonist-II (PIVKA-II] concentrations in dried blood spots were determined in 19,029 infants at about 1 month of age as an indicator of vitamin K deficiency. We observed 51 cases with raised blood concentrations of PIVKA-II (greater than 4 AU/ml), nine of whom showed very high concentrations (greater than 20 AU/ml). For infants who ...

Seventeen infants with nodular purpura are reported. All these infants suffered from a coagulation abnormality due to vitamin K deficiency. Contributing factors were breast-feeding, the use of milk substitutes, diarrhoea and antimicrobial therapy. The patients responded rapidly and completely to parenteral vitamin K. In the management of infantile diarrhoea use of antibiotics should be restrict...

Combined deficiency of vitamin K-dependent clotting factors II, VII, IX and X (and proteins C, S, and Z) is usually an acquired clinical problem, often resulting from liver disease, malabsorption, or warfarin overdose. A rare inherited form of defective gamma-carboxylation resulting in early onset of bleeding was first described by McMillan and Roberts in 1966 and subsequently has been termed '...

discussions as one ich patient whose pt and aptt suggest a coagulation disorder secondary to vitamin k deficiency or coagulation factor deficiency, unresponsiveness to vitamin k therapy should be useful to take fx deficiency into consideration. background inborn factor x deficiency (fxd) is a very rare (1: 500,000) hereditary coagulation disorder, which is characterized by clinical manifestatio...

introduction: vitamin d has an important role in maintaining human health. the main source of vitamin d production is skin exposure to sunlight. accordingly with the spread of apartment life culture, growth of industrial cities and the increase of air pollution; vitamin d deficiency and its implications is an important factor in the appearance of debilitating diseases in different age categorie...

The purpose of this review is to summarize the research to date on vitamin K status in chronic kidney disease (CKD). This review includes a summary of the data available on vitamin K status in patients across the spectrum of CKD as well as the link between vitamin K deficiency in CKD and bone dynamics, including mineralization and demineralization, as well as ectopic mineralization. It also des...

Vitamin D deficiency is one of the major health problems that is unexpectedly prevalent in Iran. The ultraviolet (UV) rays of the sunlight are the most important source of vitamin D in humans. In contrast, environmental factors are one of the reasons for decrease in UV transmission to the earth which results in the reduction of vitamin D absorption. Since the role of environmental factors has b...