AIMS The contribution of homocysteine and group B vitamins in determining cardiovascular risk is debated. We assessed the predictive value of total homocysteine (tHcy), vitamin B12, folate, and vitamin B6 on the long-term occurrence of coronary and cerebral atherothrombotic events in a nested case-control study. METHODS AND RESULTS Within a cohort of 1021 healthy subjects (490 men and 531 wom...

It is well known that among vitamin B agents those of B1 and B6 possess an inhibitory action of experimentally induced caries in animals but nothing definiteseems still unknown about the actions of B2 and anti-vitamin B6 agents. The present report is concerned with flavin adenine dinucleotide (to be abbreviated as F. A. D.) as B2, pyridoxine, 2-methy1-3-hydroxy-4-formy1-5-hydroxymethylpyridine-...

The Effects of Vitamin B6 on the Systolic Blood Pressure of Rats in Various Animal Models of Hypertension, Lal et al., Journal of Hypertension 1996, vol. 14, No. 3, 355-362. Hypotensive Action of 5-HT Receptor Agonists in the Vitamin B6-Deficient Hypertensive Rat, Lal et al., Euro pean Journal of Pharmacology, 234(1993) 183-189. Sympathetic Stimulation and Hypertension in the Pyridox ine-Defici...

Vitamin B6 is an intriguing molecule that is involved in a wide range of metabolic, physiological and developmental processes. Based on its water solubility and high reactivity when phosphorylated, it is a suitable co-factor for many biochemical processes. Furthermore the vitamin is a potent antioxidant, rivaling carotenoids or tocopherols in its ability to quench reactive oxygen species. It is...

Maternal vitamin intake during pregnancy is crucial for pregnancy outcomes and the child's subsequent health. However, there are few valid instruments for assessing vitamin intake that address the effects of nausea and vomiting during pregnancy (NVP). This study aimed to investigate the validity of a FFQ concerning vitamin intake during early and late pregnancy with and without NVP. The partici...

CONTEXT Hyperhomocysteinemia is caused by genetic and lifestyle influences, including low intakes of folate and vitamin B6. However, prospective data relating intake of these vitamins to risk of coronary heart disease (CHD) are not available. OBJECTIVE To examine intakes of folate and vitamin B6 in relation to the incidence of nonfatal myocardial infarction (MI) and fatal CHD. DESIGN Prospe...

Rats with vitamin B6 deficiency excrete cystathionine in the urine (Hope, 1957). Cystathionine is an amino acid in the pathway of synthesis of cysteine from methionine (Fig. 1). A methyl group is removed from methionine to produce homocysteine, which condenses with serine to yield cystathionine. This condensation is catalysed by a transulphurase enzyme requiring pyridoxal phosphate as a co-enzy...

conclusions no significant differences were observed between the groups based on the neonatal outcome including neonatal anthropometric parameters and lack of congenital anomaly. results there was no difference between the groups in the mean age of mother and the mean age of gestation. no differences were found between the groups regarding birth weight (3006.93 ± 441.86 versus 2949.65 ± 457.36 ...

The contents of six vitamin B6 forms, pyridoxine-β-glucoside, and 4-pyridoxic acid in mature milk of 20 Japanese lactating women consuming ordinary Japanese foods were determined by a 4-pyridoxolactone-conversion HPLC method. These compounds were determined with the average recovery rate of 83.9% or more. The average total content of vitamin B6 forms was 1.01 ± 0.32 (µmol/L). Pyridoxal and pyri...

Since Pollack (1) first noticed the urinary excretion of pyramine following in jection of 100mg of thiamine, several investigators (2, 3) have reported a similar finding. Pyramine was assumed by Mickelson (4-6) to be 2, 5-dimethyl-4aminopyrimidine or some compound related to it. Makino et al., on the other hand, have shown in mice and rats that a com pound with a similar structure, 2-methyl-5-h...