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The work is focused on the role of single components of Vitamin B complex: pyridoxine, riboflavin, thiamine, and nicotinamide in the processes of growth and development of the human brain derived cells. We, also, have assayed the activity of Xanthine Oxidase in the presence of above mentioned subcomponents to delineate the possible mechanism of their action. Results indicate that the all compon...

Vitamin B complex can modulate the inflammatory response and activate wound healing. However, the action mechanisms involved in this process are still unclear. The aim of this study was to evaluate the effects of vitamin B complex on the modulation of monocyte chemotactic protein (MCP)-1, transforming growth factor (TGF)-β1, and α-smooth muscle actin (α-SMA) in granulation tissue growth. Cutane...

PREFATORY NOTE. THROUGHOUT this paper vitamin B refers to the accessory food factors present in yeast. We have satisfied ourselves that pigeons fed on a synthetic diet of the type used throughout this work but supplemented with 4 % of yeast extract that has been heated with alkali for 4 hours to destroy the "antineuritic " factor behave exactly as do those which receive the unsupplemented ratio...

1. Values for total body vitamin B,, were calculated for eighteen patients by giving a tracer dose of radioactive cyanocobalamin and measuring the radioactivity and microbiological activity in liver biopsies obtained at laparotomy. 2. The values for total body vitamin B,, ranged from 960 to 5984pg with a mean of 2528 pg. Five values were greater and thirteen less than the mean. 3. Significant c...

It is well established that a proportion of patients with tobacco amblyopia have pernicious anaemia or some other demonstrable defect of vitamin B12 metabolism (Leishman, 195I; Heaton, McCormick, and Freeman, I958; Freeman and Heaton, I96I; Foulds, Chisholm, Bronte-Stewart, and Wilson, I968). We have examined 65 cases of tobacco amblyopia diagnosed according to the criteria of Heaton and others...

1. The histological changes of the bone marrow in fasted and rice disease pigeons are essentially the same. 2. The histological changes of the bone marrow in pure vitamin B deficiency consist of degeneration and edema and slight endothelial proliferation of the small vascular channels, but with active hematopoiesis. 3. The anemia of rice disease in pigeons is in large part a starvation anemia a...

Two phases of intestinal excretion are demonstrated after a parenteral dose of (58)Co vitamin B(12). The first phase was maximal immediately after injection, and was related to plasma radioactivity. The second phase was delayed 36 to 48 hours and was related to labelled cells reaching the tips of the villi. The loss of vitamin B(12) through increased exudation and rapid cell exfoliation togethe...