We report here the draft genome sequences of four vancomycin-intermediate Staphylococcus aureus (VISA) strains from South Korean hospitals participating in a nationwide laboratory surveillance program for vancomycin-intermediate and vancomycin-resistant Staphylococcus aureus All strains harbor mutations in the walKR, graSR, and/or rpoB genes that are known frequently mutated determinants of VISA.

The VISA+ hardware architecture is the first of a new generation of graphics accelerators designed primarily to render bump-, texture-, environmentand environment-bump-mapped olygons. This paper presents examples of the main graphical capabilities and discusses methods and simplifications used to create high quality images. One of the key concepts in the VISA + design, the use of reflectance cu...

The VISA+ hardware architecture is the first of a new genera­ tion of graphics accelerators designed primarily to render bump-, texture-, environmentand environment-bump-mapped polygons. This paper presents examples of the main graphical capabilities and discusses methods and simplifications used to create high quality images. One of the key concepts in the VISA+ design, the use of reflectance ...

Upon viral infection, retinoic acid-inducible gene I-like receptors (RLRs) recognize viral RNA and trigger a series of signaling events, leading to the induction of type I interferons (IFNs). These processes are delicately regulated to prevent excessive and harmful immune responses. In this study, we identified G patch domain-containing protein 3 (GPATCH3) as a negative regulator of RLR-mediate...

BACKGROUND This study compared the pharmacodynamics of ceftobiprole and vancomycin against methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-intermediate S. aureus (VISA) and vancomycin-resistant S. aureus (VRSA) using an in vitro model. METHODS Two methicillin-susceptible S. aureus (MSSA), two community-associated (CA)-MRSA, one healthcare-associated (HA)-MRSA, three VISA and tw...

This study analyzed clinical and microbiological characteristics of heteroresistant (hVISA) and vancomycin-intermediate Staphylococcus aureus (VISA) from bloodstream infections (BSI) in a Brazilian teaching hospital, between 2011 and 2013. Minimum inhibitory concentrations (MIC) of antimicrobials were determined by broth microdilution method and SCCmec was detected by PCR. Isolates with a vanco...

We present VISA, a graphical annotation tool for OWL-based annotation schemes with a focus on generality and usability.

We compared the potency of SMP-601, a novel carbapenem, with that of vancomycin in a murine model of hematogenous bronchopneumonia infection caused by methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-intermediate S. aureus (VISA). The MICs of SMP-601 and vancomycin against MRSA were 2 and 1 mug/ml, respectively, while those against VISA were 2 and 8 mug/ml, respectively. Treatm...

We thank Dimitrijovski and co-authors for their interest in our recent paper “Reversible antibiotic tolerance induced in Staphylococcus aureus by concurrent drug exposure” (2), but we also wish to respond here to their comments about the terminology and methods we’ve used. Regarding terminology, Dimitrijovski and colleagues (1) express concern that our use of the term “tolerance” is not in acco...