OBJECTIVE To determine the frequency and pattern of Hepatitis B and C over the past twenty one years, in a liver research unit of Karachi. METHODS Retrospective analysis of the records of PMRC, Research Centre, Jinnah Postgraduate Medical Centre, Karachi, from 1987 to 2007 were reviewed. A special flow sheet was made where information of all patients with viral liver disease was entered. Pati...

With recent advances in molecular and genomic investigations, the impact of hepatitis B viral and host factors on the progression of chronic HBV infection has been explored. For viral factors, hepatitis B viral load is a strong predictor for liver disease progression. Hepatitis B viral kinetics appear to be important for successful anti-viral therapy. Serum HBsAg level serves as a complementary...

A case of fulminant viral hepatitis type B in the late stage of pregnancy was successfully treated with glucagon-insulin therapy, corticosteroids and other drugs. A 26-year-old female (housewife and primipara) suddenly developed severe hepatic dysfunction and disturbance of consciousness at the 36th week of pregnancy. Sequential blood examinations revealed early response to HBs antibody and del...

An epidemic of viral hepatitis was studied in the Okitsu area of Shimizu city in Japan from April 1980 to November 1981. One hundred thirty-six serum samples from patients with viral hepatitis were tested for hepatitis B virus, hepatitis A virus, Epstein-Barr virus, and cytomegalovirus infection. Immunoserological data showed the outbreak of viral hepatitis to be non-A, non-B hepatitis. Epidemi...

Knowledge about hepatotropic viruses is crucial for pediatricians because of the high prevalence of viral hepatitis during childhood. The multiplicity of hepatotropic viruses, the spectrum of acute and chronic infections, and the sequels of viral hepatitis result in a need for physicians to better understand the clinical and epidemiological context of patients with viral hepatitis, as well as t...

Mankind probably has known viral hepatitis for many centuries; however, the major and most dramatic developments in our knowledge of these diseases have taken place during the second half of the 20th century. During this relatively short period of time, the infectious nature of hepatitis A, B, and C has been proven, leading to their identification and description. The advent of serologic marker...

Serological markers were used to determine the infective agents causing acute viral hepatitis in 246 patients. The frequencies of the five viral infections investigated were: non-A, non-B hepatitis 99 patients (40.2%); hepatitis A 98 patients (39.8%); hepatitis B 43 patients (17.5%); cytomegalovirus » 4 patients (1.6%); and EpsteinBarr virus 2 patients (0.8%). The log mean ages of presentation ...

DNA hybridization and cell separation techniques were used to determine which blood components contained hepatitis B viral DNA sequences. Free monomer-length hepatitis B virus was found in large amounts in the polymorphonuclear leukocyte cell fraction in two of five HBsAG-positive patients. In these two patients, viral DNA sequences were not detected in the plasma or platelet fraction, whereas ...

BACKGROUND/AIMS Mongolia has one of the highest hepatitis A, C, B and D infection incidences worldwide. We sought to investigate changes in the proportion of acute viral hepatitis types in Mongolia over the last decade. METHODS The cohort comprised 546 consecutive patients clinically diagnosed with acute viral hepatitis from January 2012 to December 2014 in Ulaanbaatar Hospital, Mongolia. A t...