Induction of the alpha1,3-fucosyltransferase FucT-VII in T lymphocytes is crucial for selectin ligand formation, but the signaling and transcriptional pathways that govern FucT-VII expression are unknown. Here, using a novel, highly phorbol myristate acetate (PMA)-responsive variant of the Jurkat T-cell line, we identify Ras and downstream mitogen-activated protein (MAP) kinase pathways as esse...

..................................................................................................... III SAMMANFATTNING ...................................................................................... V ACKNOWLEDGEMENTS............................................................................ VII OTHER WORK BY THE RESPONDENT....................................................IX TABLE O...

Maybe the first inverse problem presented in the history of the occidental thought is described in the book Republic, written by Plato. The problem is posed in the Book VII in a text known as the Allegory of the Cave. That text motivated us to formulate a simple mathematical model that simulates, in a sense, the situation of the persons described in that problem.

............................................................................................................ I SAMMANDRAG ................................................................................................. III ACKNOWLEDGEMENTS .................................................................................. V TABLE OF CONTENTS ........................................................

...........................................................................................................................................V ACKNOWLEDGMENTS...................................................................................................................VII TABLE OF CONTENTS............................................................................................................

Dystrophic epidermolysis bullosa (DEB) is an inherited mechano-bullous disorder of skin caused by mutations in the type VII collagen gene. The lack of therapy for DEB provides an impetus to develop gene therapy strategies. However, the full-length 9-kilobase type VII collagen cDNA exceeds the cloning capacity of current viral delivery vectors. In this study, we produced a recombinant type VII m...

Several studies have examined the relation between factor VII and coronary artery disease by measuring factor VII levels in plasma and some found an association between high levels and disease. This suffers problems of interpretation concerning the causality of high factor VII levels, because factor VII levels may be affected by atherogenic risk factors and may become elevated as a consequence ...

Because of the very short half-life of factor VII, prophylaxis in factor VII deficiency is considered a difficult endeavor. The clinical efficacy and safety of prophylactic regimens, and indications for their use, were evaluated in factor VII-deficient patients in the Seven Treatment Evaluation Registry. Prophylaxis data (38 courses) were analyzed from 34 patients with severe factor VII deficie...

Type VII collagen, as a major component of anchoring fibrils found at basement membrane zones, is crucial in anchoring epithelial tissue layers to their underlying stroma. Recently, type VII collagen was discovered in the inner human retina by means of immunohistochemistry, while proteomic investigations demonstrated type VII collagen at the vitreoretinal interface of chicken. Because of its po...

The effects of gamma irradiation, stearic acid alone and in combination on functional, structural and molecular characteristics of high amylose maize starch (Hylon VII) were studied. Stearic acid (0, 1.5 & 5 %) was added to Hylon VII starch, and then irradiated at 0, 30 and 60 kGy. Gamma irradiation significantly (P ≤ 0.05) increased solubility, water absorption capacity and oil absorption capa...