Abstract We place empirical constraints on the yields from zero- and low-metallicity core-collapse supernovae (CCSNe) using abundances measured in very metal-poor (VMP; [Fe/H] ≤ −2) damped Ly α absorbers (DLAs). For some abundance ratios ([N,Al,S/Fe]), VMP DLAs constrain metal of first SNe more reliably than stars. compile a large sample high-S/N over 30 yr literature, most with high-resolution...