Significant relationships exist between areal bone mineral density (BMD) derived from dual energy X-ray absorptiometry (DXA) and bone strength. However, the predictive validity of BMD for osteoporotic vertebral fractures remains suboptimal. The diagnostic sensitivity of DXA in the lumbar spine may be improved by assessing BMD from lateral-projection scans, as these might better approximate the ...

Prophylactic local treatment involving percutaneous vertebral augmentation using bioactive materials is a new treatment strategy in spine surgery in humans for vertebral bodies at risk. Standardized animal models for this procedure are almost non-existent. The purpose of this study was to: (i) prove the efficacy of PTH derivate bioactive materials for new bone formation; and (ii) create a new, ...

Chronic use of systemic glucocorticoids results in progressive bone loss and pathologic fractures. This study identified the predictive variables for bone loss and used peripheral quantitative computed tomography (pQCT) to measure changes in cortical and trabecular bone in patients receiving systemic glucocorticoid therapy of prednisone 15.4 g. Eighty-four asthmatic patients were included in th...

BACKGROUND Drug abuse is one of the most important public health problems worldwide as in Iran. The aim of present study was to determine whether opium addiction can affect bone mineral density or not. METHODS Fifty opium addicted and 50 non-addicted volunteer men aged between 25-45 were enrolled. The subjects with positive history of other osteoporosis risk factors were excluded. The vertebr...

New fan-beam DXA systems can detect vertebral fractures with fast, low-dose lateral scans of the vertebra from T4 to L4 in as little as 10 seconds. Vertebral fractures are the most common fracture in osteoporosis and an indication for treatment irrespective of Bone Mineral Density [1-3]. However, without a diagnostic test such as that available on fan-beam DXA systems, as many as 75% of vertebr...

OBJECTIVE Percutaneous vertebroplasty (PVP) is a surgical procedure that has been widely used to treat patients suffering from osteoporotic vertebral compression fractures (OVCFs). The procedure involves injection of bone cement into a fractured vertebra. In this study, we investigated whether the distribution of the cement in the vertebral body is related to the occurrence of recompression aft...

Fusions Using Recombinant Human Bone Morphogenetic Protein-2 Williams et al proposed a radiographic protocol consisting of CT scans obtained at 3, 6, and 12 months, with an additional scanning at 24 months if a solid fusion was not seen earlier in evaluating lumbar interbody fusions (LIF) (with special emphasis on using the recombinant human bone morphogenetic protein-2 [rhBMP-2] as a bone graf...

Low bone mineral density (BMD) is a strong risk factor for vertebral fracture risk in osteoporosis. However, many fractures occur in people with moderately decreased or normal BMD. Our aim was to assess the contributions of trabecular microarchitecture and its heterogeneity to the mechanical behavior of human lumbar vertebrae. Twenty-one human L(3) vertebrae were analyzed for BMD by dual-energy...

BACKGROUND Approximately one-third of vertebral fractures can be clinically diagnosed. AIM To study the frequency of vertebral fractures in postmenopausal women. PATIENTS AND METHODS We recruited 555 postmenopausal women from Santiago, Chile, aged 55-84 years, who manifested interest in their bone health. All were healthy by self-declaration and by general clinical and laboratory tests and ...

Objective: The participation of Puerto Rico in the Latin American Vertebral Osteoporosis Study (LAVOS) has allowed us to study the magnitude of the problem of osteoporosis in the female population residing in San Juan. The objective of LAVOS was to estimate the prevalence of vertebral fractures in Latin American women using a random sample of females selected from cities across five Latin Ameri...