The primary cilium is a microtubule-based structure protruded from the basal body analogous to the centriole. CPAP (centrosomal P4.1-associated protein) has previously been reported to be a cell cycle-regulated protein that controls centriole length. Mutations in CPAP cause primary microcephaly (MCPH) in humans. Here, using a cell-based system that we established to monitor cilia formation in n...

BACKGROUND Continuous positive airway pressure (CPAP) is the most widely prescribed treatment for obstructive sleep apnoea syndrome (OSAS). Although it has been shown to improve the symptoms of OSAS, many patients have difficulty adhering to this treatment. The purpose of this study was to investigate the effectiveness of an automated telemedicine intervention to improve adherence to CPAP. ME...

BACKGROUND Non-invasive continuous positive airways pressure is commonly a primary respiratory therapy delivered via multi-purpose ventilators in premature newborns. Expiratory limb occlusion due to water accumulation or 'rainout' from gas humidification is a frequent issue. A case of expiratory limb occlusion due to rainout causing unexpected and excessive repetitive airway pressurisation in a...

background: preterm labor is at risk for respiratory distress syndrome (rds) and sometimes requires to mechanical ventilation (mv) and surfactant therapy. continuous positive airway pressure (cpap) and nasal continuous positive airway pressure (ncpap) are the methods of respiratory support especially for using in rds of neonates. in other method surfactant is administered to babies via tracheal...

AIMS In acute cardiogenic pulmonary oedema (ACPE), continuous positive airway pressure (CPAP) added to medical treatment improves outcome. The present study was designed to assess the benefit of CPAP as a first line treatment of ACPE in the out-of-hospital environment. METHODS AND RESULTS The protocol lasted 45 min, divided into three periods of 15 min. Patients with ACPE were randomly assign...

Continuous positive airway pressure (CPAP) therapy is the treatment of choice for most patients with the sleep apnoea/hypopnoea syndrome. CPAP therapy is mainly used to improve daytime function but increasingly some centres are using CPAP to attempt to decrease cardiovascular risk. CPAP can be one of the most eVective forms of therapy in modern medicine. However, not all patients find this ther...

In their quest to optimise treatment strategies, neonatologists may sometimes be tempted to extrapolate results obtained during the care of very immature to more mature neonates, assuming that what is right in the former, most fragile infants cannot be wrong in the latter. A study from Tokyo, however, highlights the potential risks associated with such generalisations: in an audit of neonatal c...

OBJECTIVE To investigate the differences in breathing pattern and effort in infants at birth who failed or succeeded on continuous positive airway pressure (CPAP) during the first 48 hours after birth. METHODS Respiratory function recordings of 32 preterm infants were reviewed of which 15 infants with a gestational age of 28.6 (0.7) weeks failed CPAP and 17 infants with a GA of 30.1 (0.4) wee...

Continuous positive airway pressure (CPAP) is the treatment of choice for obstructive sleep apnoea (OSA), but compliance and variables involved in longterm CPAP adherence in women with OSA are unknown. We performed an observational study including all consecutive women diagnosed with OSA who started CPAP treatment in two Spanish teaching hospitals between 1999 and 2007 and were followed-up unti...

There are limited data on the evolution of obstructive sleep apnoea (OSA) during continuous positive airway pressure (CPAP) therapy and whether this treatment is required every night. 125 OSA patients with an original oxygen desaturation index (ODI) >10 events per hour, established on CPAP, were asked to withdraw CPAP for four nights and performed ambulatory nocturnal pulse oximetry on the four...