Abstract Background Activating transcription factor 3 (ATF3) is an early response gene that activated in to atherosclerotic stimulation and may be important inhibiting the progression of atherosclerosis. In this study, we directly measured expression ATF3 inflammatory factors human coronary plaques examine relationship between expression, inflammation structural stability plaques. Methods A tot...

Abstract Macrophages are key members of the innate immune system involved in phagocytosis, antigen presentation and other immunological functions. also important players response to tumor. Their polarization states determine role that they play tumor microenvironment (TME) generally regarded as M1-like M2-like associated macrophages (TAMs). Subsequently, TME influences how function environment....

Tobacco smoking and hemodynamic forces are key stimuli in the development of endothelial dysfunction and atherosclerosis. High laminar flow has an atheroprotective effect on the endothelium and leads to a reduced response of endothelial cells to cardiovascular risk factors compared to regions with disturbed or low laminar flow. We hypothesize that the atheroprotective effect of high laminar flo...

Maternal peripheral insulin resistance and increased inflammation are two features of pregnancies, complicated by gestational diabetes mellitus (GDM). The nucleotide-binding oligomerisation domain (NOD) intracellular molecules recognise a wide range of microbial products, as well as other intracellular danger signals, thereby initiating inflammation through activation of nuclear factor κB (NFκB...

Hyperaldosteronism is associated with hypertension, cardiovascular fibrosis, and electrolyte disturbances, including hypomagnesemia. Mechanisms underlying aldosterone-mediated Mg(2+) changes are unclear, but the novel Mg(2+) transporters TRPM6 and TRPM7 may be important. We examined whether aldosterone influences renal TRPM6/7 and the TRPM7 downstream target annexin-1 and tested the hypothesis ...