Perlecan is a heparan sulfate proteoglycan assembled into the vascular basement membranes (BMs) during vasculogenesis. In the present study we have investigated vessel formation in mice, teratomas and embryoid bodies (EBs) in the absence of perlecan. We found that perlecan was dispensable for blood vessel formation and maturation until embryonic day (E) 12.5. At later stages of development 40% ...

Portal hypertension (PH) is a common complication and a leading cause of death in patients with chronic liver diseases. PH is underlined by structural and functional derangement of liver sinusoid vessels and its fenestrated endothelium. Because in most clinical settings PH is accompanied by parenchymal injury, it has been difficult to determine the precise role of microvascular perturbations in...

La luxation sous-talienne est une perte de rapports anatomiques entre l'astragale, calcanéum et scaphoïde. C'est une lésion rare, elle représente 1% de toutes les luxations observées en traumatologie. Nous rapportons le cas d'une patiente de 40 ans, sans antécédents, ayant subi un traumatisme de son pied droit lors de la réception d'un saut d'un lieu élevé d'un mètre (mécanisme en inversion du ...

Behçet’s disease (BD) is a multisystem inflammatory disorder. Intracardiac thrombus (ICT) formation is an uncommon but important complication of BD. Of the cases of Behçet’s disease, we selected those with ICT. All patients fulfilled the diagnostic criteria of the International Study Group of Behçet’s disease. The ICT in each case was confirmed by ultrasonography, computed tomography and MRI. C...

The CCN family of proteins is composed of six extracellular matrix-associated proteins that play crucial roles in skeletal development, wound healing, fibrosis, and cancer. Members of the CCN family share four conserved cysteine-rich modular domains that trigger signal transduction in cell adhesion, migration, proliferation, differentiation, and survival through direct binding to specific integ...

Polypoidal Choroidal Vasculopathy (PCV), a subtype of neovascular Age-related Macular Degenerationn (AMD) is disease characterized by persistent, recurrent serous leakage and hemorrhage in the macular area, mostly seen elderly population. While contemporary science offers anti Vasculo Endothelial Growth Factor (VEG-F) monotherapy combination with Photodynamic Therapy (PDT), outcomes these remai...

L'association fracture de la diaphyse fémorale et fracture de Hoffa de l'extrémité inférieure du même fémur est très rare, peu de cas sont décrit dans la littérature. Elles surviennent après un traumatisme à haute énergie surtout lors des accidents de la voie publique. Elles touchent par conséquent une population jeune. Notre patient est âgé de 27 ans, il a été victime d'un accident grave en co...

Hemangiomas are frequent benign tumors of the liver. Symptoms (abdominal pain and fullness) are mostly seen in giant lesions. Rupture is the most severe complication, can occur spontaneously, with intraperitoneal bleeding, in 1-4% of hemangiomas and has been described in about 30 cases in the international literature with a high mortality (about 60%). This complication is the principal indicati...

beta1 integrins are important regulators of vascular differentiation and development, as their endothelial-specific deletion results in embryonic lethality. In the present study, we investigated the molecular mechanisms underlying the prominent vascular abnormalities that occur in the absence of beta1 integrins. Because of the early embryonic lethality of knockout mice, we studied endothelial c...

Exposure to chemical substances (including alkylating chemical warfare agents like sulfur and nitrogen mustards) cause a plethora of clinical symptoms including wound healing disorder. The physiological process of wound healing is highly complex. The formation of granulation tissue is a key step in this process resulting in a preliminary wound closure and providing a network of new capillary bl...