INTRODUCTION Antibiotic resistance is a rapidly emerging problem. A major concern is methicillin-resistant Staphylococcus aureus (MRSA), especially in developing countries where cost-effectiveness is imperative. Restriction of vancomycin usage is necessary to reduce the emergence of vancomycin-resistant organisms. The aim of this study was to look into the appropriate use of vancomycin based on...

We report three patients infected with unique strains of vancomycin-dependent enterococci. Two were first infected by genetically identical strains of vancomycin-resistant enterococci (VRE). All three patients had much greater exposure to vancomycin and third-generation cephalosporins than did two control groups (patients infected with VRE and hospitalized patients without enterococcal infectio...

aim & background : enterococci infections are public health growing concern due to the glycopeptide antibiotics resistance especially vancomycin. genes, vana, b, and h, are contributed to the influence of vancomycin-resistant enterococci (vre). this investigation aims at exploring the vre frequency and the rate of each genes in isolated enterococci from gastroenteritis patients in central regio...

Title of Document: VANCOMYCIN GROUP ANTIBIOTICS: FROM AN UNDERSTANDING OF BIOSYNTHESIS AND RESISTANCE TO IMPROVING UPON NATURE’S DESIGN James J. Gorman Master of Life Science with a concentration in chemistry 2008 Directed By: Dr. Philip DeShong, Organic Chemistry Methicillin-resistant Staphylococcus aureus (MRSA) infections are not simply relegated to healthcare associated event anymore. News ...

results disk diffusion agar showed that 96 strains (48%) were resistant to gentamicin, 89 (44.5%) to ciprofloxacin, 127 (63.5%) to erythromycin, 142 (71%) to tetracycline, 11 (5.5%) to teicoplanin, 32 (16%) to vancomycin, none to linezolid and 96 (48%) to co-trimoxazole. the mics of the resistant isolates were as follows; 88 strains had mic ≥ 32 μg/ml to vancomycin and 59 strains had mic ≥ 32 μ...

background: increasing antimicrobial resistance is now a critical point of human being in the world. especially wide spectrum antibiotics resistance germs like vancomycin-resistant enterococci (vre) should be dealt as soon as possible as an emergency conflict. our study tries to reveal the amount of irrational use of vancomycin in a teaching hospital in iran. methods: we elected the whole inpat...

Glycopeptides of the clinically important antibiotic drugs are glycosylated cyclic or polycyclic nonribosomal peptides. Glycopeptides such as vancomycin and teicoplanin are often used for the treatment of gram-positive bacteria in patients. The increased incidence of drug resistance and inadequacy of these therapeutics against gram-positive bacterial infections would be the formation and clinic...

The high prevalence of methicillin resistance among Staphylococcus aureus bacteremias leads to common use of vancomycin as empirical therapy. However, investigators have reported poor outcomes with vancomycin treatment for methicillin-susceptible Staphylococcus aureus bacteremia. We review the evidence supporting empirical combination of both vancomycin and a β-lactam agent for Staphylococcus a...

A 1-month old neonate urine sample yielded vanB Enterococcus faecium; nevertheless, the isolate alternatively showed susceptibility and resistance to vancomycin with bioMérieux Vitek2 (cards AST592, AST632, AST586), while glycopeptide resistance was detected by Liofilchem® vancomycin MIC Test Strip and disc along with the Chromatic VRE chromogenic medium. This communication emphasizes that, as ...