Expectant management of fetal death complicated by placenta previa occurring during midtrimester trimester may induce fetal/placental atrophy and decrease uterine blood flow to facilitate vaginal delivery. Our experience with these cases suggests that about 4 weeks of expectant management should be considered as a management strategy.

PURPOSE This study evaluates the efficacy of Vacuum constrictive device (VCD) and the reasons for its failure. MATERIALS AND METHODS In this cross-sectional study, 1500 men with organic erectile dysfunction(ED) were enrolled from July 2003 to July 2010. The treatment efficacy was analyzed using International Index of Erectile Function (IIEF) and questioning patient's partner regarding the man...

The evisceration of the bowel through vaginal vault is an extremely rare condition and a surgical emergency with high-reported mortality rate. Vaginal most commonly affects menopausal women hysterectomy or those previous surgery. common risk factors include triad post-menopausal atrophy, surgery enterocele. Estrogen deficiency in leads to weaker pelvic support structures thin, atrophic vagina, ...

BACKGROUND Atrophic vaginitis is a disease, which affects up to 50% of postmenopausal women. This study compared the effectiveness and user-friendliness of Vagifem (an estradiol vaginal tablet) and vaginal estrogen cream in the treatment of atrophic vaginitis. MATERIALS AND METHODS One hundred and sixty postmenopausal women with symptoms of atrophic vaginitis were randomly divided into two gr...

OBJECTIVE The aim of the study was to evaluate the safety and efficacy of vaginal estradiol (E2) softgel capsules for moderate-to-severe symptoms of vulvar and vaginal atrophy (VVA). Previous phase 1 studies showed lower systemic estrogen concentrations with this softgel capsule compared with an approved low-dose vaginal E2 tablet. METHODS In this randomized, double-blind, placebo-controlled ...

OBJECTIVE To evaluate the response of the vaginal mucosa with TX-004HR and its correlation with vulvar and vaginal atrophy (VVA) symptoms, and whether visual examination is a useful measure for assessing VVA. METHODS REJOICE was a 12-week, phase 3, multicenter, randomized, double-blind, placebo-controlled study of a vaginal, muco-adhesive, 17β-estradiol softgel capsule (TX-004HR 4, 10, and 25...

BACKGROUND The 12-week, randomized, double-blind, placebo-controlled, multicenter, phase 3 REJOICE trial demonstrated that TX-004HR, an investigational, applicator-free, low-dose vaginal softgel capsule containing solubilized 17β-estradiol, effectively and rapidly treats symptoms of vulvar and vaginal atrophy (VVA) with negligible to very low systemic absorption. The aim of this analysis was to...

BACKGROUND: The changes in vaginal acidity impact the composition of microbiota, either commensal or pathogenic. After menopause, tract is more susceptible to infection. Current study was conducted analyze effect on microbiota menopausal women.METHODS: A cross-sectional 32 subjects with vulvovaginal atrophy (VVA). Vaginal pH measured using a strip colorimetric examination. detection Candida sp....

OBJECTIVE The aim of this exploratory pilot study was to determine if there are differences in vaginal cytokine levels between postmenopausal women with and without vulvovaginal irritative symptoms (itching, burning, or pain). METHODS Postmenopausal women (n = 34) not using hormone therapy and presenting with or without symptoms of vulvovaginal irritation were asked to volunteer for this stud...