نتایج جستجو برای: v notch
تعداد نتایج: 321822 فیلتر نتایج به سال:
چکیده ملانومای متاستاتیک یکی از چالش برانگیزترین سرطان ها در حوزه درمان است. مطالعات اخیر نشان میدهند، سلول های بنیادی سرطان مسئول ایجاد متاستاز، مقاومت دارویی و بازگشت مجدد تومور هستند. این خصوصیات سلول های بنیادی به اختلال در مسیرهای پیام رسانی سلولی مانندnotch و wnt نسبت داده می شود و هدفگیری این مسیرها می تواند دستاورهای درمانی تازه ای را برای سرطان به همراه داشته باشد؛ اما تاکنون نقش مسیر...
OBJECTIVES The relative contributions of inflammatory signalling and sequential oncogenic dysregulation driving liver cancer pathogenesis remain incompletely understood. Lymphotoxin-β receptor (LTβR) signalling is critically involved in hepatitis and liver tumorigenesis. Therefore, we explored the interdependence of inflammatory lymphotoxin signalling and specific oncogenic pathways in the prog...
BACKGROUND The suprascapular notch, a depression on the lateral part of the superior border of the scapula, medial to the coracoid process, is bridged by the superior transverse scapular ligament, which is sometimes ossified and the foramen which is thus completed, transmits the suprascapular nerve to the supraspinatus fossa. Variations in the morphology of suprascapular notch have been identif...
The topic of this thesis is the investigation of the local states of stress resulting from the introduction of a v-notch in a coaxial circle on the pressurized surface of a circumferentially clamped plate subject to axisymmetric loading. The understanding of the fracture behavior of a component experiencing such a condition is of particular interest to the aerospace and defense industries where...
Periodic noises are unwished and spurious signals that create repetitive pattern on images and decreased the visual quality. Firstly, this paper investigates various methods for reducing the effects of the periodic noise in digital images. Then an adaptive optimum notch filter is proposed. In the proposed method, the regions of noise frequencies are determined by analyzing the spectral of noisy...
Fine-grained steels belonging to the HSLA group (High-Strength Low-Alloy steels) of are becoming increasingly popular and used in both statically dynamically stressed structures. Due method their production, thus also use obtain required mechanical properties, it is really necessary limit heat input values for these during welding. When applying temperature cycles, highly heated heat-affected z...
The Drosophila wing imaginal disc gives rise to three body parts along the proximo-distal (P-D) axis: the wing blade, the wing hinge and the mesonotum. Development of the wing blade initiates along part of the dorsal/ventral (D/V) compartment boundary and requires input from both the Notch and wingless (wg) signal transduction pathways. In the wing blade, wg activates the gene vestigial (vg), w...
A 24 year old otherwise healthy male was presented with a chief complaint of giving way in the left knee. MRI reportedcomplete anterior cruciate ligament (ACL) tearing. Arthroscopy showed ACL agenesis, ring-shaped lateral meniscus,and an anomalous thick band extending from the anterior horn of the lateral meniscus to the intercondylar notch of thelateral femoral condyle, which...
The vertebrate spinal cord has long served as a useful system for studying the pattern of cell differentiation along the dorsoventral (d/v) axis. In this paper, we have defined the expression of several classes of genes expressed in restricted d/v domains in the intermediate region (IR) of the mouse spinal cord, in which most interneurons are generated. From this analysis, we have found that sp...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید