BACKGROUND Hereditary syndromes frequently need the cooperation of different specialties to increase diagnostic competence. Multiple cutaneous and uterine leiomyomatosis syndrome is a rare autosomal dominant disorder caused by the mutations of the fumarate hydratase gene, demonstrated in 80 to 100 percent of affected individuals. This can be linked to an increased risk of renal cancer in both s...

Realistic generation of variable anatomical organ models and pathologies are crucial for a sophisticated surgical training simulator. A training scene needs to be different in every session in order to exhaust the full potential of virtual reality based training. We previously reported on a cellular automaton able to generate leiomyomas found in the uterine cavity. This paper presents an altern...

We demonstrated that the expression of 14-3-3 gamma was lower in uterine leiomyomas compared to the adjacent normal myometrium. Here, we show that 14-3-3 gamma promoter is methylated more in leiomyomas than myometrium. The level of 14-3-3 gamma protein in leiomyomas did not change in respect to age, size, location, or the type of leiomyoma. ER-alpha, ER-beta, and PR proteins were also higher in...

UNLABELLED The aim of this study was to investigate the relationship between the tumor uptake of 16α-(18)F-fluoro-17β-estradiol ((18)F-FES) and (18)F-FDG using PET and expressions of sex hormone receptors, such as estrogen receptor (ER), as well as glucose transporter 1 (GLUT-1) and Ki-67 analyzed by the immunohistochemistry method in mesenchymal uterine tumors. METHODS Forty-seven patients w...

Uterine fibroids are most common benign uterine neoplasm occurring in 20-30% of reproductive age. Generally, the sonographic appearance leiomyomas is characteristic; however, they can undergo various kind degenerations that dramatically change their and make diagnosis quite challenging. We hereby describe a case report 31-year-old women who presented with menorrhagia dysmenorrhoea her imaging a...

OBJECTIVE Despite the high prevalence of uterine leiomyoma in women, little is known about the pathophysiology of this tumor. This study intends to define the epigenetic modulation of this tumor. METHODS Twenty-three pairs of leiomyomas and their adjacent myometria were collected. Status of DNA global methylation was determined by using DNA methyl acceptance assay and immunohistochemistry sta...

The spectrum of uterine smooth muscle cell tumours (SMT) ranges from leiomyomas to leiomyosarcomas (LMS). Atypical (AL) are a SMT contentious nature due its indeterminate malignant potential. Although the risk recurrence is low there limited experience on management. On other hand, it generally believed that LMS arises de novo, rather than precursor lesion.

Uterine leiomyoma is the most common benign tumor of genital tract. The etiology of myomas is unknown. Leiomyoma shows a broad spectrum of radiographic appearances depending on the number, size, and location of the tumor. The diagnostic method for uterine leiomyomas is based primarily on the clinical situation. Despite of the varied diagnostic options such as; transvaginal sonography, sonohyste...

Thirty-six leiomyomas from the same number of patients that were heterogeneous on MR imaging were evaluated for analyzing their MR patterns and for differentiating each type of secondary changes by means of MR imaging-pathologic correlation. The tumors with a mean diameter of 9 cm could be classified into 4 patterns depending on the morphological appearance of signal intensity: speckled (n = 14...