Hwang GS, Yang JY, Ryu DH, Kwon TH. Metabolic profiling of kidney and urine in rats with lithium-induced nephrogenic diabetes insipidus by H-NMR-based metabonomics. Am J Physiol Renal Physiol 298: F461–F470, 2010. First published November 18, 2009; doi:10.1152/ajprenal.00389.2009.—Lithium (Li) treatment for bipolar affective disorders is associated with a variety of renal side effects. The meta...

s 75 Biochemical monitoring of sodium valproate in children W. Whitehouse, H. Seddon, M. Preece & A. Green Department of Paediatric Neurology and the Regional Inherited Metabolic Disease Laboratory, Birmingham Children’s Hospital, Birmingham, UK Sodium valproate (VPA) is an effective anti-epileptic drug (AED) in infancy. However. it has been associated with sometimes fatal adverse effects on li...

s 75 Biochemical monitoring of sodium valproate in children W. Whitehouse, H. Seddon, M. Preece & A. Green Department of Paediatric Neurology and the Regional Inherited Metabolic Disease Laboratory, Birmingham Children’s Hospital, Birmingham, UK Sodium valproate (VPA) is an effective anti-epileptic drug (AED) in infancy. However. it has been associated with sometimes fatal adverse effects on li...

s 75 Biochemical monitoring of sodium valproate in children W. Whitehouse, H. Seddon, M. Preece & A. Green Department of Paediatric Neurology and the Regional Inherited Metabolic Disease Laboratory, Birmingham Children’s Hospital, Birmingham, UK Sodium valproate (VPA) is an effective anti-epileptic drug (AED) in infancy. However. it has been associated with sometimes fatal adverse effects on li...

to day, the activated carbon is being used to treat the industrial and domestic wastewaters. the suitability of activated carbon for treatment of industrial wastewaters can be quickly predicted by consideration of wastewater characteristics. the results of this paper represent a first step in determining suitability of activated carbon for treatment of wastewaters or effluent of treatment plant...

Normalized median, minimum, and maximum values (analytical concentration factors) are given for 134 organic acids in urine of nine adult control subjects, five juvenile control subjects, and five children with neuroblastoma. The organic acids, separated by anion-exchange chromatography, were analyzed by a gas chromatograph-mass spectrometer-computer system. Sixty substances in this fraction are...

A rapid and accurate quantitative method was developed and validated for the analysis of four urinary organic acids with nitrogen containing functional groups, formiminoglutamic acid (FIGLU), pyroglutamic acid (PYRGLU), 5-hydroxyindoleacetic acid (5-HIAA), and 2-methylhippuric acid (2-METHIP) by liquid chromatography tandem mass spectrometry (LC/MS/MS). The chromatography was developed using a ...

ReDuNing injection, prepared from a combination of Gardenia Jasminoides fruits, Lonicera japonica flower buds, and the Artemisia annua aerial part, is extensively used for treatment of viral upper respiratory tract infections in China. Iridoids, organic acids, and flavonoids are likely important compounds of the herbal injection because of their reported pharmacological properties. This study w...

Glutaric aciduria type II (GA II) was proved in a neonate who presented shortly after birth with respiratory distress, metabolic acidosis, non-ketotic hypoglycaemia and a sweaty-feet-like odour. The diagnosis was based on elevated levels of glutaric and other acids in the urine and on studies on cultured skin fibroblasts where defective metabolism of fatty acids of varying chain length was demo...