INTRODUCTION Urine neutrophil gelatinase-associated lipocalin (uNGAL) is a sensitive and specific diagnostic test for acute kidney injury (AKI) in the Emergency Department (ED), but its economic impact has not been investigated. We hypothesized that uNGAL used in combination with serum creatinine (sCr) would reduce costs in the management of AKI in patients presenting to the ED in comparison to...

BACKGROUND AND OBJECTIVES The outcome of renal transplantation after an episode of acute rejection is difficult to predict, even with an allograft biopsy. We examined whether urinary expression of specific biomarker mRNA could be used as a noninvasive prognostic marker in kidney transplant recipients. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS We studied 63 kidney transplant recipients who...

OBJECTIVE The aim of our study is to describe the changes in urinary and serum levels of novel biomarkers after gadolinium contrast administration in patients with normal renal function. METHODS We measured four biomarkers in 28 volunteers: interleukin-18 (IL-18), N-acetyl-glucosaminidase (NAG), neutrophil gelatinase-associated lipocalin, and cystatin C. Urinary and serum samples were collect...

chronic kidney disease (ckd) is an increasing cause of morbidity and mortality worldwide. prospective data on risk factors for ckd are few. hypertension is one of the risk factors for ckd. in the past serum creatinine concentration was used as marker of kidney function but it proffers a late reflection of reduced glomerular filtration rate(gfr), which limits its ability to detect impaired kidne...

results the infusion group had a lower plasma pai-1 level compared to the subcutaneous group at day 7 (11.3 ± 1.6 vs. 16.5 ± 4.2; p = 0.003). the urinary ngal level was lower in the infusion group at day 2 (131.3 ± 11.9 vs. 151.2 ± 20.6; p = 0.014); however, at day 7 the ngal level was decreased in the subcutaneous group as much as the infusion group and there was no significant difference betw...

Introduction Acute kidney injury (AKI) occurs frequently after abdominal aortic surgery and there is currently no effective marker able to detect early onset. The aim of this study is to evaluate the ability of neutrophil gelatinase-associated lipocalin (NGAL) to early identify the development of acute renal damage in patients undergoing endovascular aneurysm repair (EVAR) or open aortic repair...

background: acute kidney injury (aki) is a common and life-threatening complication following coronary artery bypass graft (cabg). neutrophil gelatinase-associated lipocalin (ngal) and cystatin c have shown to be good predictive factors for aki. recently, there has been a growing interest in the use of hypertonic saline in cardiac operations. the purpose of this study was to evaluate the prophy...

Background. Neutrophil gelatinase-associated lipocalin (NGAL) in serum and urine have been suggested as potential early predictive biological markers of acute kidney injury (AKI) in selected critically ill patients. Methods. We performed a secondary analysis of a multicenter prospective observational cohort study of unselected critically ill patients. Results. The analysis included 140 patients...

BACKGROUND Sensitive and specific biomarkers for early tubulointerstitial injury are lacking. HYPOTHESIS The excretion of certain urinary proteins will correlate with the state of renal injury in dogs with chronic kidney disease. ANIMALS Twenty-five male colony dogs affected with X-linked hereditary nephropathy (XLHN) and 19 unaffected male littermates were evaluated. METHODS Retrospectiv...