We investigated the polymorphic enzymes cytochrome P450 1A2 (CYP1A2), N-acetyltransferase (NAT2), glutathione S-transferase (GST) M1 (GSTM1), and T1 (GSTT1) in relation to cigarette smoking-associated urinary mutagenicity detected on YG1024 Salmonella typhimurium strain with S9 mix in 97 smokers. In each subject, cigarette smoke intake was checked by analysis of urinary nicotine plus its metabo...

Mucopolysaccharidosis IIIA (MPS IIIA) is a lysosomal storage disorder (LSD) caused by deficiency of N-sulphoglucosamine sulphohydrolase, which one four enzymes involved in heparan sulfate degradation. Traditional methods used for MPS diagnostics usually constitute selective screening, based on the analysis urinary glycosaminoglycans, further enzymatic assays leukocytes, and mutation analysis. N...

Background: The kidneys perform glomerular filtration, tubular reabsorption, and tubular secretion and the study of urinary excretion of some enzymes considered as a sensitive test for the detection of early stages of renal disease, particularly N-acetyl-β-D-glucosaminidase (NAG) which is a hydrolytic lysosomal enzyme present in the epithelial cells of the proximal convoluted tubule. Increased ...

introduction: aim was to study the influence of serum testosterone and urinary citrate on the formation of urinary stones in men and women, and to apply the findings for preventing urolithiasis. methods: we studied 200 patients (100 were men and 100 women) who had referred to the urology clinic at imam khomeini hospital and seda sima eswl center. in both groups, 50 were stone formers and 50 wer...

Glutathione S-transferase (GST), a member of the phase II group of xenobiotic metabolizing enzymes, has been intensively studied at the levels of phenotype and genotype. The GST mu 1 (GSTM1) and GST theta 1 (GSTT1) genes have a null-allele variant in which the entire gene is absent. The null genotype for both enzymes has been associated with many different types of tumors. The aim of this study...

conclusions multiple associations existed between atrophic urogenital changes and urinary incontinence. the most significant interaction was between urinary tract infections and urinary incontinence in menopausal women, with urinary tract infections increasing the risk of incontinence by 5.6 fold. we recommend health professionals to focus on early screening of these issues and implement educat...

a study was designed to evaluate the normal value of 24 hr urinary calcium levels in the city of yazd. the average urinary excretion of calcium in a sample of 329 persons randomly selected was 232 mg/day, while patients with a history of recurrent urolithiasis excreted 20x mg/day. there is evidence which shows that more important factors than the amount of urinary calcium exist which influence ...

The urinary ratio of 6 beta-hydroxycortisol/cortisol (6 beta-OHC/C) as a biomarker of CYP3A4 metabolizing activity has been studied in Egyptian patients with chronic liver cirrhosis associated with previous hepatic Schistosomiasis infection to determine any possible alteration in enzyme activity. The ratio of 6-beta OHC/C was determined in morning urine samples collected from 8:00 a.m. to 12:00...

1. The activities of the enzymes histidase, urocanase and histidine-pyruvate transaminase were studied in rats under conditions of protein malnutrition. Urocanase and histidase activities in liver were markedly lowered in experimental protein malnutrition, but the activity of histidine-pyruvate transaminase was unaffected. There is a metabolic control in vivo of the enzymes involved in the cata...

In view of Mattenheimer's comprehensive review of enzymes in renal disease in this journal only four years ago, major emphasis has been placed at the recent Symposium on Diagnostic Significance of Enzymes and Proteins in Urine held at Kanderstag, Switzerland in March of 1978. The pathophysiology of enzyme release in renal disease is presented, the current status of enzyme measurement reviewed, ...