349 male patients with uncomplicated gonococcal urethritis were treated with a single dose of 300 mg. or 400 mg. minocycline hydrochloride. The lower dose gave a lower failure rate, 3-2 compared with 5-1 per cent., but this difference was not statistically significant. The overall known failure rate of 4-2 per cent. compares most favourably with our previous findings in this area using other dr...

Trobicin (Actinospectacin) is a new antibiotic obtained from Streptomyces spectabilis developed by the Research Laboratories of Messrs. Upjohn. It is prepared as a white powder, 1 4-1 6 g. of which is dissolved in distilled water. It has been stated to have a wide range of antibacterial activity and has already been shown (Willcox, 1962) to be effective in cases of acute gonorrhoea in males whe...

ViewPoint:Gentamicin for treatment of gonococcal urethritis in Malawi Gift Kamanga1, Chisale Mhango2, Lillian B. Brown3 1.University of North Carolina project, Kamuzu Central Hospital 2.Ministry of Health, Reproductive Health Unit 3..University of North Carolina at Chapel hill Gonococcal urethritis continues to be a public health problem in Malawi. Urethritis accounts for over 20% of outpatient...

Of 84 men with non-gonococcal urethritis (NGU), 24 yielded Chlamydia trachomatis by either cell culture or MicroTrak immunofluorescence test. All 84 were treated with bacampicillin 800 mg twice a day for seven days. Five (one chlamydia positive) defaulted from follow up 10 to 14 days after the start of treatment. Of the 23 chlamydia positive patients who attended follow up, 22 became chlamydia ...

Metronidazole (8823 RP; "Flagyl") is a nitroinidazole derivative which has been shewn to be highly active against T. vaginalis, not only in the laboratory (Cosar and Julou, 1959) but also in vivo against human trichomoniasis in the female (Durel, Roiron, Siboulet, and Borel, 1959, 1960; Durel, Couture, Collart, and Girot, 1960; Nicol, Barrow, and Redmond, 1960; Rodin, King, Nicol, and Barrow, 1...

Of 62 men with non-gonococcal urethritis who entered a study to assess compliance with treatment with oxytetracycline, only 33 could be evaluated. Traditional methods (interview and the absence of oxytetracycline in the urine) showed incomplete compliance in nine. Use of low dose phenobarbitone as a pharmacological marker showed incomplete compliance in a further five patients. In addition, phe...

The relationship between Trachoma-Inclusion Conjunctivitis agents (TRIC Agents) and Non-Specific urethritis (NSU) was investigated. The results of complement fixation and immunofluorescence studies using a "group" and a "type-specific" antigen/antiserum are presented in detail, as well as other associated clinical and laboratory findings related to a routine evaluation of urethritis. It was sho...

OBJECTIVES To examine the effects of urethritis and its treatment on semen plasma HIV-1 RNA load in HIV-1 infected men not receiving antiretroviral therapy (ART), in a developed world setting. METHODS Prospective case-control study. HIV-1 infected homosexual men, not receiving ART for at least 3 months, with (cases) and without (controls) symptomatic urethritis, were recruited. Blood and seme...